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Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction

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We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, Angipur administered intravenously was 1.2 times less effective, in terms of ED50, than the well-known inhibitor of GPIIb/IIIa platelet receptors tirofiban. However, under conditions of non-coronary myocardial infarction, Angipur significantly prolonged the time of thrombus formation and exhibited 1.4-fold higher activity than the reference drug tirofiban.

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Authors and Affiliations

  1. Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia

    A. A. Spasov, A. F. Kucheryavenko, N. A. Gurova, V. S. Sirotenko & K. A. Gaidukova

  2. Department of Pharmaceutical Chemistry with Courses of Analytical and Toxicological Chemistry, Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, the Republic of Bashkortostan, Russia

    F. A. Khaliullin, A. V. Samorodov & V. N. Pavlov

Authors
  1. A. A. Spasov
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  2. A. F. Kucheryavenko
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  3. F. A. Khaliullin
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  4. N. A. Gurova
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  5. V. S. Sirotenko
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  6. A. V. Samorodov
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  7. K. A. Gaidukova
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  8. V. N. Pavlov
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Corresponding author

Correspondence to V. S. Sirotenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 303-306, September, 2021

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Spasov, A.A., Kucheryavenko, A.F., Khaliullin, F.A. et al. Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction. Bull Exp Biol Med 172, 314–317 (2022). https://doi.org/10.1007/s10517-022-05383-9

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  • DOI: https://doi.org/10.1007/s10517-022-05383-9

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