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Correlation of Physiological Parameters in Rats after Stress Exposure under Conditions of Antigenic Stimulation with Lipopolysaccharide Administration

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied correlation dependences between physiological parameters in rats in 3 h, 1 day, and 8 days after administration of LPS (100 μg/kg) at the end of 24-h immobilization stress. In 3 h after LPS administration against the background of stress exposure, significant correlations of metabolic parameters with the relative weight of the adrenal glands and the perceptual component of nociception in rats were revealed. A direct relationship between the concentration of the proinflammatory cytokine TNFα and anti-inflammatory IL-4 was also found in these animals. On the first day after LPS injection, correlations were revealed, predominantly positive, only between the indicators of the cytokine blood profile. In the late post-stress period after antigenic exposure, no correlations between the studied physiological parameters were found. It can be hypothesized that immune modulation through systemic administration of LPS prevents persistent excessive stress of physiological functions at the later stages after stress exposure.

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References

  1. Abramova AY, Pertsov SS, Alekseeva IV, Nikenina EV, Kozlov AY, Chekhlov VV, Chukhnina ME. Blood Cytokine Concentration in Rats during Antigenic Treatment after a Single Long-Term Stress Exposure. Bull. Exp. Biol. Med. 2020;168(6):713-717. doi: https://doi.org/10.1007/s10517-020-04786-w

    Article  CAS  PubMed  Google Scholar 

  2. Alekseeva IV, Abramova AY, Kozlov AY, Koplik EV, Pertsov AS, Lyadov DA, Nikenina EV, Pertsov SS. State of Stress-Marker Organs in Rats after a Single Exposure to Long-Term Stress and Treatment with Lipopolysaccharide. Bull. Exp. Biol. Med. 2019;167(5):624-627. doi: https://doi.org/10.1007/s10517-019-04584-z

    Article  CAS  PubMed  Google Scholar 

  3. Degtyarev VP, Pertsov SS. Neurophysiology. Moscow, 2018. Russian.

  4. Ketlinskii SA, Simbirtsev AS. Cytokines. St. Petersburg, 2008. Russian.

  5. Korneva EA, Shanin SN, Novikova NS, Pugach VA. Cellmolecular basis ofneuroimmune interactions during stress. Ross. Fiziol. Zh. 2017;103(3):217-229. Russian.

    CAS  Google Scholar 

  6. Morozov BB. Actual Problems of Pathophysiology (Selected Lectures). Moscow, 2001. Russian.

    Google Scholar 

  7. Pertsov SS. Melatonin in Systemic Mechanisms of Emotional Stress. Moscow, 2011. Russian.

  8. Pertsov SS, Alekseeva IV, Abramova AYu, Kozlov AYu, Koplik EV, Lyadov DA, Nikenina EV, Chekhlov VV. Influence of lipopolysaccharide on nociceptive sensitivity of rats after one-time long stressing load. Ross. Zh. Boli. 2019;17(3):11-17. Russian.

    Google Scholar 

  9. Pertsov SS, Alekseeva IV, Abramova AYu, Nikenina EV, Kozlov AYu, Koplik EV, Martyusheva AS. Metabolic parameters in rats at various stages of the post-stress period under conditions of antigenic exposure by administration of lipopolysaccharide. Ross. Fiziol. Zh. 2021;107(3):321-331. doi: https://doi.org/10.31857/S0869813921030080. Russian.

    Article  Google Scholar 

  10. Baral P, Udit S, Chiu IM. Pain and immunity: implications for host defence. Nat. Rev. Immunol. 2019;19(7):433-447. doi: https://doi.org/10.1038/s41577-019-0147-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cook AD, Christensen AD, Tewari D, McMahon SB, Hamilton JA. Immune cytokines and their receptors in inflammatory pain. Trends Immunol. 2018;39(3):240-255. doi: https://doi.org/10.1016/j.it.2017.12.00

    Article  CAS  PubMed  Google Scholar 

  12. de Oliveira CM, Sakata RK, Issy AM, Gerola LR, Salomão R. Cytokines and pain. Rev. Bras. Anestesiol. 2011;61(2):255-259, 260-265, 137-142. doi: https://doi.org/10.1016/S0034-7094(11)70029-0

  13. Płóciennikowska A, Hromada-Judycka A, Borzęcka K, Kwiatkowska K. Co-operation of TLR4 and raft proteins in LPSinduced pro-inflammatory signaling. Cell. Mol. Life Sci. 2015;72(3):557-581. doi: https://doi.org/10.1007/s00018-014-1762-5.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia

    I. V. Alekseeva, A. Yu. Abramova & S. S. Pertsov

Authors
  1. I. V. Alekseeva
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  2. A. Yu. Abramova
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  3. S. S. Pertsov
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Correspondence to I. V. Alekseeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 7, pp. 14-19, July, 2021

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Alekseeva, I.V., Abramova, A.Y. & Pertsov, S.S. Correlation of Physiological Parameters in Rats after Stress Exposure under Conditions of Antigenic Stimulation with Lipopolysaccharide Administration. Bull Exp Biol Med 172, 9–13 (2021). https://doi.org/10.1007/s10517-021-05320-2

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  • DOI: https://doi.org/10.1007/s10517-021-05320-2

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