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Rat Blood Leukocytes after Intravenous Injection of Magnetoliposomes on the Basis of Nanomagnetite

  • BIOTECHNOLOGIES
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Bulletin of Experimental Biology and Medicine Aims and scope

The structure of blood neutrophils, eosinophils, monocytes, and lymphocytes and differential white blood count in adult rats were studied over 120 days after a single intravenous injection of magnetoliposomes based on nanomagnetite. Magnetoliposomes had no effect on the structure of neutrophils, eosinophils, monocytes, and lymphocytes. At the same time, injection of a suspension of magnetoliposomes based on magnetite nanoparticles led to a decrease in lymphocyte count and an increase in the count of monocytes and band and segmented neutrophils in the blood. These changes were transient and the parameters returned to normal by day 40-60 after injection.

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Authors and Affiliations

  1. Department of Morphology and General Pathology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    I. V. Mil’to, V. V. Ivanova, N. M. Shevtsova, O. N. Serebryakova, E. A. Gereng & I. V. Sukhodolo

  2. Department of Molecular and Cellular Radiology, Seversk Biophysical Research Center, Federal Medical-Biological Agency, Seversk, Russia

    I. V. Mil’to & R. M. Takhauov

  3. Common Use Center “Physico-Сhemical Analysis Methods”, National Research Tomsk Polytechnic University, Tomsk, Russia

    A. A. Ivanov

Authors
  1. I. V. Mil’to
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  2. V. V. Ivanova
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  3. N. M. Shevtsova
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  4. O. N. Serebryakova
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  5. A. A. Ivanov
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  6. E. A. Gereng
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  7. R. M. Takhauov
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  8. I. V. Sukhodolo
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Correspondence to I. V. Mil’to.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 6, pp. 766-770, June, 2021

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Mil’to, I.V., Ivanova, V.V., Shevtsova, N.M. et al. Rat Blood Leukocytes after Intravenous Injection of Magnetoliposomes on the Basis of Nanomagnetite. Bull Exp Biol Med 171, 774–777 (2021). https://doi.org/10.1007/s10517-021-05314-0

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  • DOI: https://doi.org/10.1007/s10517-021-05314-0

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