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Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson’s Disease

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A Correction to this article was published on 19 November 2021

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A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.

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Authors and Affiliations

  1. Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia

    E. D. Kryl’skii, G. A. Razuvaev, T. N. Potapova, A. I. Akinina & L. E. Nihaev

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  1. E. D. Kryl’skii
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  2. G. A. Razuvaev
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  3. T. N. Potapova
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  4. A. I. Akinina
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  5. L. E. Nihaev
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Corresponding author

Correspondence to E. D. Kryl’skii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 6, pp. 701-707, June, 2021

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Kryl’skii, E.D., Razuvaev, G.A., Potapova, T.N. et al. Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson’s Disease. Bull Exp Biol Med 171, 716–721 (2021). https://doi.org/10.1007/s10517-021-05302-4

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  • DOI: https://doi.org/10.1007/s10517-021-05302-4

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