We studied the localization and severity of morphological changes in CNS and internal organs of animals intacerebrally infected with a low-attenuated rubella virus strain “Orlov-14”. The data obtained can be used as morphological criteria reflecting low level of attenuation of rubella virus strains to improve the control of the safety of attenuated strains of live rubella vaccines.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 5, pp. 651-655, May, 2021
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Shamsutdinova, O.A., Bulgin, D.V., Karal-Ogly, D.D. et al. Analysis of Morphological Changes in the CNS and Internal Organs of Macaca mulatta Monkeys after Intracerebral Injection of a Low-Attenuated Rubella Virus Strain. Bull Exp Biol Med 171, 671–675 (2021). https://doi.org/10.1007/s10517-021-05291-4
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DOI: https://doi.org/10.1007/s10517-021-05291-4