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Cytoprotective and Antioxidant Effects of Meconic Acid in Model Systems

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the antioxidant and cytoprotective effects of meconic acid in the model systems. Meconic acid, similar to commercial drug Mexidol, reduced the intensity of chemiluminescence in the model system of yolk lipoproteins. Meconic acid also reduced the toxic effect of glutamate on neurons in the primary cerebellar culture, but had no effect on cell viability under normal conditions.

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References

  1. Vasil’ev RF, Veprintsev TL, Naumov VV, Trofimov AV, Tsaplev YB, Dolmatova LS. Kinetics of ethylbenzene oxy-chemiluminescence in the presence of antioxidants from tissues of the marine invertebrate eupentacta fraudatrix: estimating the concentration and reactivity of the natural antioxidants. Kinetics Catalysis. 2014;55(2):148-153.

  2. Kozin SV, Kravtsov AA, Elkina AA, Zlishcheva EI, Shurygina LV, Baryshev MG, Barysheva EV, Moiseev AV. Isotope exchange of deuterium for protium in rat brain tissues changes brain tolerance to hypoxia. Biophysics. 2019;64(2):272-278.

    Article  CAS  Google Scholar 

  3. Kondratenko RV, Chepkova AN, Shurygin AY, Skrebitskii VG. Comenic acid prevents post-stress enhancement of long-term potentiation in rat hippocampus. Bull. Exp. Biol. Med. 2003;136(5):464-466. https://doi.org/10.1023/b:bebm.0000017094.26711.fc

    Article  CAS  PubMed  Google Scholar 

  4. Kravtsov AA, Shurygin AY, Skorokhod NS, Khaspekov LG. Neuroprotector effect of comenic acid against cytotoxic action of glutamate in vitro in cultured neurons of lead-poisoned rat pups. Bull. Exp. Biol. Med. 2011;150(4):436-439. https://doi.org/10.1007/s10517-011-1162-x

    Article  CAS  PubMed  Google Scholar 

  5. Krylov BV, Lopatina EV. Patent RU No. 2322977. Synthetic analgesic agent and method for treatment based on this agent. Bull. No. 12. Published April 27, 2008.

  6. Rogachevskii IV, Plakhova VB, Domnin IN, Podzorova SA, Krylova BV. Physiological role of γ-pyrone. Klin. Patofiziol. 2006;(1):15-23. Russian.

    Google Scholar 

  7. Stelmashook EV, Genrikhs EE, Isaev NK, Chetverikov NS, Golyshev SA. Thymoquinone induces mitochondrial damage and death of cerebellar granule neurons. Biochemistry (Moscow). 2020;85(2):205-212.

    Article  CAS  Google Scholar 

  8. Shurygin AYa. Baliz Drug. Krasnodar, 2002. Russian.

  9. Shurygina LV, Zlishcheva EI, Kravtsov AA. Antioxidant properties of comenic acid and its calcium salt under experimental stress conditions. Eksp. Klin. Farmakol. 2018;81(4):3-7. https://doi.org/10.30906/0869-2092-2018-81-4-3-7. Russian

    Article  CAS  Google Scholar 

  10. Shurygina LV, Zlishcheva EI, Kravtsov AA. Neurotrophic Action of Comenic Acid and Its Derivatives Potassium Comenate and Calcium Comenate. Bull. Exp. Biol. Med. 2018;165(4):465-469. https://doi.org/10.1007/s10517-018-4195-6

    Article  CAS  PubMed  Google Scholar 

  11. Shurygina LV, Zlishcheva EI, Kravtsova AN, Kravtsov AA. Antioxidant and Antiamnestic Effects of Potassium Comenate and Comenic Acid under Conditions of Normobaric Hypoxia with Hypercapnia. Bull. Exp. Biol. Med. 2017;163(3):344-348. https://doi.org/10.1007/s10517-017-3800-4

    Article  CAS  PubMed  Google Scholar 

  12. Shurygina LV, Kravtsov AA, Kozin SV, Zlishcheva EI, Abramova NO. Antioxidative activity of Astragalus membranaceus (Fabaceae) root and aerial parts extracts in two model systems. Rastit. Resursy. 2017;53(2):291-299. Russian.

    Google Scholar 

  13. Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC. Neuronal cell death. Physiol. Rev. 2018;98(2):813- 880. https://doi.org/10.1152/physrev.00011.2017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Kim DS, Kim SJ, Kim MC, Jeon YD, Um JY, Hong SH. The therapeutic effect of chelidonic acid on ulcerative colitis. Biol. Pharm. Bull. 2012;35(5):666-671. https://doi.org/10.1248/bpb.35.666

    Article  CAS  PubMed  Google Scholar 

  15. Lovell S, Subramony P, Kahr B. Poppy acid: synthesis and crystal chemistry. J. Am. Chem. Soc. 1999;121(30):7020-7025. https://doi.org/10.1021/ja990402a

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Kuban State University, Krasnodar, Russia

    S. V. Kozin, A. A. Kravtsov, S. V. Kravchenko & L. I. Ivashchenko

  2. Federal Research Center South Research Center, Russian Academy of Sciences, Rostovon-Don, Russia

    S. V. Kozin & A. A. Kravtsov

Authors
  1. S. V. Kozin
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  2. A. A. Kravtsov
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  3. S. V. Kravchenko
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  4. L. I. Ivashchenko
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Corresponding author

Correspondence to S. V. Kozin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 5, pp. 592-595, May, 2021

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Kozin, S.V., Kravtsov, A.A., Kravchenko, S.V. et al. Cytoprotective and Antioxidant Effects of Meconic Acid in Model Systems. Bull Exp Biol Med 171, 619–622 (2021). https://doi.org/10.1007/s10517-021-05281-6

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  • DOI: https://doi.org/10.1007/s10517-021-05281-6

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