We studied the effect of 3-, 24-, and 72-h exposure to H2O2 in concentrations of 0.1-100.0 μM on the level of constitutive androstane receptor in Caco-2 cells. It was shown that 3- and 24-h incubation with Н2О2 in all concentrations had no effect on the level of constitutive androstane receptors. Increasing the incubation time to 72 h led to an increase in the level of constitutive androstane receptor at H2O2 concentrations of 5, 10, and 50 μM and to a decrease at a concentration of 100 μM. Antioxidant glutathione (1 mM) in parallel to the prooxidant neutralized these changes.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 5, pp. 588-591, May, 2021
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Shchul’kin, A.V., Abalenikhina, Y.V., Seidkulieva, A.A. et al. Induction of Constitutive Androstane Receptor during the Development of Oxidative Stress. Bull Exp Biol Med 171, 615–618 (2021). https://doi.org/10.1007/s10517-021-05280-7
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DOI: https://doi.org/10.1007/s10517-021-05280-7