Skip to main content
SpringerLink
Log in

The Role of the Hippocampus in the Neuroendocrine Response to Neurobiological Stimuli in Experiment

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We compared the levels of functional activity of cells in each adrenal zone with blood levels of corticosterone, testosterone, and neuropeptide Y in control and hippocampectomized F1(C57BL/6×DBA/2) mice during modeling of metabolic, motivational, and cognitive tension. The morphofunctional state of the adrenal glands was studied using a new morphometric approach. It was found that hippocampectomy changed the testosterone response to neurobiological stimuli; similar changes were observed in the zona reticularis of the adrenal cortex producing dehydroepiandrosterone that is involved in the regulation of testosterone secretion. At the same time, hippocampectomy enhanced the response of the peptide hormone; the index of functional activity of chromaffin cells producing this hormone also increased. These findings allow us to put forward a hypothesis that the hippocampus is involved in the regulation of mutual influences of the studied hormones and that it modulates the sensitivity of testosterone and NPY to metabolic and cognitive factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Volkov VP. The functional morphology of adrenal cortex in age. Sovremen. Med.: Aktual. Vopr. 2014;(31):16-26. Russian.

  2. Lushnikova EL, Nepomnyashchikh LM, Koldysheva EV, Molodykh OP. Adrenal glands: ultrastructural reorganization under extreme influences and aging. Moscow, 2009. Russian.

  3. Serkova VV, Nikol’skaya KA. Effects of spatial imprinting on the development of the cognitive process in adult animals. Neurosci. Behav. Physiol. 2015;45(6):684-692.

    Article  Google Scholar 

  4. Allen CD, Waser B, Körner M, Reubi JC, Lee S, Rivier C. Neuropeptide Y acts within the rat testis to inhibit testosterone secretion. Neuropeptides. 2011;45(1):55-61. doi: https://doi.org/10.1016/j.npep.2010.10.006

    Article  CAS  PubMed  Google Scholar 

  5. Davidson TL, Kanoski SE, Chan K, Clegg DJ, Benoit SC, Jarrard LE. Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behav. Neurosci. 2010;124(1):97-105. doi: https://doi.org/10.1037/a0018402

    Article  PubMed  PubMed Central  Google Scholar 

  6. Herman JP, McKlveen JM, Ghosal S, Kopp B, Wulsin A, Makinson R, Scheimann J, Myers B. Regulation of the hypothalamic-pituitary-adrenocortical stress response. Compr. Physiol. 2016;6(2):603-621. doi: https://doi.org/10.1002/cphy.c150015

    Article  PubMed  PubMed Central  Google Scholar 

  7. Joëls M. Corticosteroids and the brain. J. Endocrinol. 2018;238(3):R121-R130. doi: https://doi.org/10.1530/JOE-18-0226

    Article  PubMed  Google Scholar 

  8. Malva JO, Xapelli S, Baptista S, Valero J, Agasse F, Ferreira R, Silva AP. Multifaces of neuropeptide Y in the brain--neuroprotection, neurogenesis and neuroinflammation. Neuropeptides. 2012;46(6):299-308. doi: https://doi.org/10.1016/j.npep.2012.09.001

    Article  CAS  PubMed  Google Scholar 

  9. Retana-Márquez S, Bonilla-Jaime H, Vázquez-Palacios G, Martínez-García R, Velázquez-Moctezuma J. Changes in masculine sexual behavior, corticosterone and testosterone in response to acute and chronic stress in male rats. Horm. Behav. 2003;44(4):327-337. doi: https://doi.org/10.1016/j.yhbeh.2003.04.001

    Article  CAS  PubMed  Google Scholar 

  10. Tobiansky DJ, Korol AM, Ma C, Hamden JE, Jalabert C, Tomm RJ, Soma KK. Testosterone and corticosterone in the mesocorticolimbic system of male rats: effects of gonadectomy and caloric restriction. Endocrinology. 2018;159(1):450-464. doi: https://doi.org/10.1210/en.2017-00704

    Article  CAS  PubMed  Google Scholar 

  11. Tolchennikova VV, Nikolskaya KA, Kondashevskaya MV. “Behavior” of the hormonal ensemble through the prism of cluster analysis. Bull. Exp. Biol. Med. 2020;169(4):531-534. doi: https://doi.org/10.1007/s10517-020-04923-5

    Article  CAS  PubMed  Google Scholar 

  12. Vilà-Balló A, Mas-Herrero E, Ripollés P, Simó M, Miró J, Cucurell D, López-Barroso D, Juncadella M, Marco-Pallarés J, Falip M, Rodríguez-Fornells A. Unraveling the role of the hippocampus in reversal learning. J. Neurosci. 2017;37(28):6686-6697. doi: https://doi.org/10.1523/JNEUROSCI.3212-16.2017

    Article  PubMed  PubMed Central  Google Scholar 

  13. Vollmer LL, Schmeltzer S, Schurdak J, Ahlbrand R, Rush J, Dolgas CM, Baccei ML, Sah R. Neuropeptide Y impairs retrieval of extinguished fear and modulates excitability of neurons in the infralimbic prefrontal cortex. J. Neurosci. 2016;36(4):1306-1315. doi: https://doi.org/10.1523/JNEUROSCI.4955-13.2016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. West KS, Roseberry AG. Neuropeptide-Y alters VTA dopamine neuron activity through both pre- and postsynaptic mechanisms. J. Neurophysiol. 2017;118(1):625-633. doi: https://doi.org/10.1152/jn.00879.2016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Yan XS, Yang ZJ, Jia J.X, Song W, Fang X, Cai ZP, Huo DS, Wang H. Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer’s disease. Neural Regen. Res. 2019;14(4):649-657. doi: https://doi.org/10.4103/1673-5374.245477

Download references

Author information

Authors and Affiliations

  1. Research Institute of Human Morphology, Moscow, Russia

    M. V. Kondashevskaya

  2. M. V. Lomonosov Moscow State University, Moscow, Russia

    K. A. Nikolskaya & V. V. Tolchennikova

Authors
  1. M. V. Kondashevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. A. Nikolskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Tolchennikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. V. Kondashevskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 4, pp. 513-518, April, 2021

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kondashevskaya, M.V., Nikolskaya, K.A. & Tolchennikova, V.V. The Role of the Hippocampus in the Neuroendocrine Response to Neurobiological Stimuli in Experiment. Bull Exp Biol Med 171, 494–498 (2021). https://doi.org/10.1007/s10517-021-05258-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-021-05258-5

Key Words

Search

Navigation