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Peculiarities of the Composition of Peripheral Immune Cells and Cytokine Profile in Brain Structures in Mutant DISC1-L100P Mice

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Intact Disc1-L100P mice carrying a point mutation DISC1Rgsc1390 in the second exon of the DISC1 gene (genetic model of schizophrenia) differ from the parental C57BL/6NCrl strain by higher content of CD3+ T cells and reduced number of CD19+B cells in the peripheral blood and spleen. Analysis of T cell subpopulations revealed an increase in the number of CD3+CD4+ T helpers in the blood of mutant mice and a decrease in the level of CD3+CD8+ suppressor/cytotoxic T cells and CD3+CD4+CD25+ T-regulatory cells. The distribution pattern of inflammatory (IL-1β, IL-2, IL-6, IL-17, IFNγ, and TNFα) and anti-inflammatory (IL-4, IL-10) cytokines specific for Disc1-L100P mice was revealed in the brain structures involved in the pathogenesis of schizophrenia. A possible implication of immune mechanisms in the development of schizophrenia-like endophenotype of Disc1-L100P mice is discussed.

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Authors and Affiliations

  1. Research Institute of Neuroscience and Medicine, Novosibirsk, Russia

    E. L. Al’perina, M. M. Gevorgyan, S. Ya. Zhanaeva, T. V. Lipina & G. V. Idova

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  1. E. L. Al’perina
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  2. M. M. Gevorgyan
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  3. S. Ya. Zhanaeva
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  4. T. V. Lipina
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  5. G. V. Idova
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Corresponding author

Correspondence to G. V. Idova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 3, pp. 328-332, March, 2021

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Al’perina, E.L., Gevorgyan, M.M., Zhanaeva, S.Y. et al. Peculiarities of the Composition of Peripheral Immune Cells and Cytokine Profile in Brain Structures in Mutant DISC1-L100P Mice. Bull Exp Biol Med 171, 347–351 (2021). https://doi.org/10.1007/s10517-021-05225-0

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  • DOI: https://doi.org/10.1007/s10517-021-05225-0

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