Skip to main content
Log in

Pathomorphological Changes in the Brain in Dynamics of Long-Term Dust Exposure

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Histological and morphometric studies of brain autopsy material showed that the development of hypoxic changes in miners starts at the early stages of working in the dusty atmosphere. Edema of the pericellular and perivascular zones and the pia mater, degenerative changes in some nerve cells and even their loss and formation of gliosis foci were identified. The revealed changes in neurons progressed with increasing the duration of working under hazardous conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Velitchkovsky BT. Pathogenesis and classification of dust diseases. Med. Truda Prom. Ekol. 2003;(7):8-13. Russian.

    Google Scholar 

  2. Vetrovoy OV, Rybnikova EA, Samoilov MO. Cerebral mechanisms of hypoxic/ischemic postconditioning. Biochemistry (Moscow). 2017;82(3):392-400.

    Article  CAS  Google Scholar 

  3. Droblenkov AV, Naumov NV, Monid MV, Valkovich EI, Shabanov PD. Reactive changes of the rat brain cellular elements under different conditions of circulatory hypoxia. Morfologiya. 2013;143(3):14-21. Russian.

    CAS  Google Scholar 

  4. Zhukova AG, Sazontova TG, Arkhipenko YuV, Volkov AV. Gender differences in the pro- and antioxidant systems of the brain in the late postresuscitative period (an experimental study). Obshch. Reanimatol. 2010;6(4):54-57. Russian.

    Article  Google Scholar 

  5. Zhukova AG, Ulanova EV, Fomenko DV, Kazitskaya AS, Yadykina TK. Specificity of cellular response to various occupational toxicants. Med. Truda Prom. Ekol. 2011;(7):23-26. Russian.

    Google Scholar 

  6. Chebotarev AG. Current working environment at mines and ways of its improvement. Gornaya Prom. 2012;(2):84-88. Russian.

    Google Scholar 

  7. Chebotarev AG. Working environment and occupational morbidity of mine personnel. Gornaya Prom. 2018;(1):92-95. doi: 10.30686/1609-9192-2018-1-137-92-95. Russian.

  8. Chertok VM, Nevzorova VA, Zakharchuk NV, Chertok AG. The comparative characteristic of the neurons containing the hypoxia-inducible factor lalpha and 2alpha in the brain of rats at hypertension. Tsitologiya. 2018;60(11):883-888. doi: https://doi.org/10.1134/S0041377118110032. Russian.

    Article  Google Scholar 

  9. Armutcu F, Gun BD, Altin R, Gurel A. Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience. Environ. Toxicol. Pharmacol. 2007;24(2):106-113. doi: https://doi.org/10.1016/j.etap.2007.03.002

    Article  CAS  PubMed  Google Scholar 

  10. Batool AI, Naveed NH, Aslam M, da Silva J, Rehman MFU. Coal dust-induced systematic hypoxia and redox imbalance among coal mine workers. ACS Omega. 2020;5(43):28204-28211. doi: https://doi.org/10.1021/acsomega.0c03977

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cui X, Xing J, Liu Y, Zhou Y, Luo X, Zhang Z, Han W, Wu T, Chen W. COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study. Cell Stress Chaperones. 2015;20(3):473- 481. doi: 10.1007/s12192-015-0572-5

  12. Wang H, Xing J, Wang F, Han W, Ren H, Wu T, Chen W. Expression of Hsp27 and Hsp70 in lymphocytes and plasma in healthy workers and coal miners with lung cancer. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2010;30(4):415-420. doi: https://doi.org/10.1007/s11596-010-0441-5

    Article  CAS  Google Scholar 

  13. Zakharenkov VV, Mikhailova NN, Zhdanova NN, Gorokhova LG, Zhukova AG. Experimental study of the mechanisms of intracellular defense in cardiomyocytes associated with stages of anthracosilicosis development. Bull. Exp. Biol. Med. 2015;159(4):431-434. doi: https://doi.org/10.1007/s10517-015-2983-9

    Article  CAS  PubMed  Google Scholar 

  14. Zhukova AG, Mikhailova NN, Sazontova TG, Zhdanova NN, Kazitskaya AS, Bugaeva MS, Gorokhova LG, Arkhipenko YV. Participation of free-radical processes in structural and metabolic disturbances in the lung tissues caused by exposure to coal-rock dust and their adaptogenic correction. Bull. Exp. Biol. Med. 2020;168(4):439-443. doi: https://doi.org/10.1007/s10517-020-04727-7

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. G. Zhukova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 2, pp. 228-231, February, 2021

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bugaeva, M.S., Bondarev, O.I., Mikhailova, N.N. et al. Pathomorphological Changes in the Brain in Dynamics of Long-Term Dust Exposure. Bull Exp Biol Med 171, 258–261 (2021). https://doi.org/10.1007/s10517-021-05207-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-021-05207-2

Key Words

Navigation