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Age-Related Features of the Response of the Liver and Stem Cells during Modeling of Liver Cirrhosis

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the age-related characteristics of the response of stem cells and liver in male Wistar rats to administration of carbon tetrachloride (CCl4) and ethanol. It was shown that modeling of liver cirrhosis caused inflammation, fibrosis, damage to sinusoidal capillaries, necrosis, and disturbances in the functional activity of hepatocytes in young rats. These processes were accompanied by mobilization of profibrotic mesenchymal stem cells (MSC), proinflammatory hematopoietic stem cells (HSC) and lymphocytes (CD45hiCD133+) from the bone marrow into the blood and migration to the liver. On the other hand, the number of hepatocyte precursors expressing Sox9 (cells of Hering’s canal), immature cholangiocytes, Ito cells, oval cells, and endothelial cells of the liver sinusoids) sharply increased in the liver. In young rats, mobilization and migration of MSC, HSC, and hepatocyte precursors against the background of liver cirrhosis were more intensive than in old animals. The higher resistance of old rats to exposure is associated with age-related changes in the niches as well as in mobilization and migration of cells.

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Authors and Affiliations

  1. Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

    E. G. Skurikhin, E. S. Pan, N. N. Ermakova, O. V. Pershina, A. V. Pakhomova, O. D. Putrova, L. A. Sandrikina, V. A. Krupin & A. M. Dygai

  2. Medical and Pharmaceutical College of the Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    M. A. Zhukova

  3. Department of Pharmacology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    L. V. Kogai

  4. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    A. M. Dygai

  5. Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk, Russia

    T. Yu. Rebrova & S. A. Afanas’ev

Authors
  1. E. G. Skurikhin
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  2. M. A. Zhukova
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  3. E. S. Pan
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  4. N. N. Ermakova
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  5. O. V. Pershina
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  6. A. V. Pakhomova
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  7. O. D. Putrova
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  8. L. A. Sandrikina
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  9. V. A. Krupin
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  10. L. V. Kogai
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  11. T. Yu. Rebrova
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  12. S. A. Afanas’ev
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  13. A. M. Dygai
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Corresponding author

Correspondence to E. G. Skurikhin.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 24-30, March, 2021

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Skurikhin, E.G., Zhukova, M.A., Pan, E.S. et al. Age-Related Features of the Response of the Liver and Stem Cells during Modeling of Liver Cirrhosis. Bull Exp Biol Med 171, 127–133 (2021). https://doi.org/10.1007/s10517-021-05184-6

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  • DOI: https://doi.org/10.1007/s10517-021-05184-6

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