Skip to main content

Advertisement

SpringerLink
Log in

Influence of Surgical Treatment and Neoadjuvant Therapy of Chemically Induced Breast Cancer on Correlation of Cytokine Concentrations in the Lymph with Structural Transformations in the Mesenteric Lymph Nodes

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We performed a correlation analysis of the morphometry of mesenteric lymph nodes and cytokines of the thoracic duct lymph in chemically induced breast cancer (BC) and after surgical treatment of BC and neoadjuvant chemotherapy for BC according to the CMF scheme. After surgical treatment, correlations were found between the level of cytokines in the thoracic duct lymph and morphological changes in the mesenteric lymph nodes. The observed correlations can be a result of total resection of the tumor and increased immunomodulatory and antitumor action of cytokines. Comparison of the effect of chemotherapy and surgical treatment revealed correlations between cytokine concentrations in the lymph and structural changes in the lymph nodes, which can be related to weakening of local immunity and antitumor effect of cytokines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kabakov AV, Lykov AP, Morozov DV, Kazakov OV, Poveshchenko AF, Raiter TV, Strunkin DN, Konenkov VI. Phenotypical Characteristics of Chemically Induced Mammary Tumor. Bull. Exp. Biol. Med. 2017;163(4):490-492. doi: https://doi.org/10.1007/s10517-017-3835-6

    Article  CAS  PubMed  Google Scholar 

  2. Poveshchenko AF, Kazakov OV, Orlov NB, Poveshchenko OV, Kim II, Bondarenko NA, Solovieva IG, Strunkin DN, Kabakov AV, Rayter TV, Lykov AP, Bogachev SS, Pokushalov EA, Konenkov VI. Lymph cytokines as markers oncogenesis and effective treatment of experimental breast cancer Wistar rat. Patol. Fiziol. Eksp. Ter. 2016;60(3):68-75. Russian.

    CAS  PubMed  Google Scholar 

  3. Sosnina AV, Velikaya NV, Autenshlyus AI. Role of Cytokines in the Pathogenesis of Malignant Tumors. Novosibirsk, 2013. Russian.

  4. Shipilov MV, Ivanov VV. Th17 response in acute respiratory viral infections of various origin. Tsitokiny Vospalenie. 2012;11(1):109-113. Russian.

    Google Scholar 

  5. Di Paolo N. C, Shayakhmetov D.M. Interleukin 1α and the inflammatory process. J. Nat. Immunol. 2016;17(8):906-913. doi: https://doi.org/10.1038/ni.3503

    Article  CAS  Google Scholar 

  6. Esendagli G, Yilmaz G, Canpinar H, Gunel-Ozcan A, Guc MO, Guc D. Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats. Lab. Anim. 2009;43(1):60-64. doi: https://doi.org/10.1258/la.2008.007076

    Article  CAS  PubMed  Google Scholar 

  7. Hamza T, Barnett JB, Li B. Interleukin 12 a key immunoregulatory cytokine in infection applications. Int. J. Mol. Sci. 2010;11(3):789-806. doi: https://doi.org/10.3390/ijms11030789

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am. J. Pathol. 2007;170(2):774-786. doi: https://doi.org/10.2353/ajpath.2007.060761

    Article  PubMed  PubMed Central  Google Scholar 

  9. Huang HY, Luther SA. Expression and function of interleukin- 7 in secondary and tertiary lymphoid organs. Semin. Immunol. 2012;24(3):175-189. doi: https://doi.org/10.1016/j.smim.2012.02.008

    Article  CAS  PubMed  Google Scholar 

  10. Meneses A, Verastegui E, Barrera JL, de la Garza J, Hadden JW. Lymph node histology in head and neck cancer: impact of immunotherapy with IRX-2. Int. Immunol. 2003;3(8):1083-1091. doi: https://doi.org/10.1016/S1567-5769(03)00017-1

    Article  CAS  Google Scholar 

  11. Sugama S, Conti B. Interleukin-18 and stress. Brain Res. Rev. 2008;58(1):85-95. doi: https://doi.org/10.1016/j.brainresrev.2007.11.003

    Article  CAS  PubMed  Google Scholar 

  12. Tsubura A, Lai YC, Miki H, Sasaki T, Uehara N, Yuri T, Yoshizawa K. Review: animal models of N-Methyl-N-nitrosoureainduced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011;25(1):11-22.

    CAS  PubMed  Google Scholar 

  13. Williams IR. CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis. Ann. N.Y. Acad. Sci. 2006;1072):52-61. doi: https://doi.org/10.1196/annals.1326.036

Download references

Author information

Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia

    O. V. Kazakov, A. F. Poveshchenko, N. B. Orlov, O. V. Poveshchenko, A. V. Kabakov, T. V. Raiter, A. P. Lykov & V. I. Konenkov

  2. Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    D. N. Strunkin & L. F. Gulyaeva

  3. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    A. N. Sultanova

Authors
  1. O. V. Kazakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. N. Strunkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. F. Poveshchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. B. Orlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. V. Poveshchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. V. Kabakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. N. Sultanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T. V. Raiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. P. Lykov
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. L. F. Gulyaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. V. I. Konenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. V. Kazakov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 1, pp. 86-91, January, 2021

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kazakov, O.V., Strunkin, D.N., Poveshchenko, A.F. et al. Influence of Surgical Treatment and Neoadjuvant Therapy of Chemically Induced Breast Cancer on Correlation of Cytokine Concentrations in the Lymph with Structural Transformations in the Mesenteric Lymph Nodes. Bull Exp Biol Med 171, 68–73 (2021). https://doi.org/10.1007/s10517-021-05174-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-021-05174-8

Key Words

Search

Navigation