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Comparative Characterization of Lymphoid Infiltration in Different Molecular-Biological Subtypes of Invasive Breast Cancer

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The morphometric study examined the cell profile of lymphoid structures and leukocytic infiltrates in mammary glands of women with different molecular-biological subtypes of invasive breast cancer (BC). A high degree of lymphoid infiltration with the formation of lymphoid nodules was typical of luminal B (LumB) subtype of BC characterized by high tumor proliferation index (Ki-67≥30%) and in triple negative BC with Ki-67 ranging 33-35%. In these BC subtypes, extensive necrotic foci and pronounced stromal fibrosis of the mammary glands were observed. Lymphoid clusters and nodules predominantly consisted of B cells (CD20+) and T helper cells (CD4+). Cytotoxic lymphocytes (CD8+) were mostly observed in interstitial infiltrates. Macrophages and plasma cells were primarily located near the tumor cells. The presence of lymphoid clusters in the form of lymphoid nodules and dense lymphoid infiltrates can be viewed as unfavorable sign during diagnosis of BC and prediction of the course of the tumor process.

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References

  1. Beznos OA, Burov DA, Sel’chuk VYu, Vorotnikov IK, Timoshenko VV, Grigor’eva TA, Vishnevskaya Ya. V, Tupitsyn NN. Interrelation of tumor infiltrating lymphocyte subpopulations with clinical and pathomorphological features of a breast cancer. Opukholi Zhensk. Reprod. Sistemy. 2016;12(2):13-17. doi: https://doi.org/10.17650/1994-4098-2016-12-2-13-17. Russian.

    Article  Google Scholar 

  2. Bessmeltsev S, Semenova N, Rugal V. Lymphoid microenvironment in chronic lymphocytic leukemia. Sovremen. Probl. Nauki Obrazovaniya. 2013;(5). URL: http://www.science-education.ru/ru/article/view?id=10318. Russian.

  3. Zabotina TN, Korotkova OV, Borunova AA, Tabakov DV, Bokin II, Panichenko IV, Savostikova MV, Samoylenko IV, Tsiklauri VT, Khakimova ShG, Kadagidze ZG. Multiparameter study of the immunophenotype of tumor infiltrating lymphocytes, in cancer patients. Ross. Onkol. Zh. 2016;21(1):51-54. Russian.

    Article  Google Scholar 

  4. Kazachkov EL, Semenova AB, Shamanova AY. Structural features of inflammatory cell infiltrates in around cancer area and distant zone invasive cancers nonspecific type breast in association with tumor grade. Ural. Med. Zh. 2014;(8):33-36. Russian.

    Google Scholar 

  5. Kiselevskiy MV, Vlasenko R Ya, Zabotina TN, Kadagidze ZG. Prognostic significance of tumor-infiltrating lymphocytes. Immunologiya. 2019;40(1):74-83. doi: https://doi.org/10.24411/0206-4952-2019-11009. Russian.

  6. Sazonov SV, Brilliant AA, Brilliant Yu. M. Proliferative processes and features of tumor cell receptor apparatus of the breast carcinoma. Geny Kletki. 2017;12(4):76-81. doi: https://doi.org/10.23868/201707033. Russian.

    Article  Google Scholar 

  7. Bozhok AA, Semiglazov VF, Semiglazov VV, Arzumanov AS, Kletsel AE. Prognostic and predictive factors in breast cancer. Vopr. Onkol. 2005;51(4):434-443. Russian.

    CAS  PubMed  Google Scholar 

  8. Demidov S, Sazonov S, Brilliant A, Brilliant Y. Expression of WNT, Hedgehog and NOTCH signaling pathways in HER-2 overexpressed and triple negative subtypes of breast cancer with high and low content of cancer stem cells. Ann. Oncol. 2020;31(Suppl. 2):S30. https://doi.org/https://doi.org/10.1016/j.annonc.2020.03.176

  9. Disis ML. Immune regulation of cancer. J. Clin. Oncol. 2010;28(29):4531-4538. doi: https://doi.org/10.1200/JCO.2009.27.2146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Eggermont AMM. Can immune-oncology of a truly pan-tumor approach to therapy? Ann. Oncol. 2012;23(Suppl. 8):viii53-7. doi: https://doi.org/10.1093/annonc/mds264

  11. Kim R, Emi M, Tanabe K. Cancer immunoediting from immune surveillance to immune escape. Immunology. 2007;121(1):1-14. doi: https://doi.org/10.1111/j.1365-2567.2007.02587.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer. 2012;12(4):252-264.

    Article  CAS  Google Scholar 

  13. Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331:1565-1570. doi: https://doi.org/10.1126/science.1203486.

    Article  CAS  PubMed  Google Scholar 

  14. Sazonov SV, Konyshev KV. HER2/Neu in local metastases and primary focus of breast cancer. Virchows Archiv. 2015;467(S1):S55.

    Google Scholar 

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Authors and Affiliations

  1. Research Institute of Human Morphology, Moscow, Russia

    L. M. Erofeeva & M. V. Mnikhovich

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  1. L. M. Erofeeva
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  2. M. V. Mnikhovich
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Correspondence to L. M. Erofeeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 1, pp. 80-85, January, 2021

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Erofeeva, L.M., Mnikhovich, M.V. Comparative Characterization of Lymphoid Infiltration in Different Molecular-Biological Subtypes of Invasive Breast Cancer. Bull Exp Biol Med 171, 62–67 (2021). https://doi.org/10.1007/s10517-021-05173-9

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  • DOI: https://doi.org/10.1007/s10517-021-05173-9

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