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On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy

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The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ (p=0.00001), Ерас1 (p=0.021), and Ерас2 (p=0.018) and receptors RyR2 (p=0.0031) and IP3R2 (p=0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals (p<0.05). These changes were accompanied by echocardiographically documented decrease in the degree of left ventricle remodeling and improvement of its inotropic function.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    S. A. Kryzhanovskii, L. M. Kozhevnikova, M. B. Vititnova, A. O. Efimova, V. N. Stolyaruk & I. B. Tsorin

  2. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    L. M. Kozhevnikova

Authors
  1. S. A. Kryzhanovskii
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  2. L. M. Kozhevnikova
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  3. M. B. Vititnova
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  4. A. O. Efimova
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  5. V. N. Stolyaruk
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  6. I. B. Tsorin
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Corresponding author

Correspondence to S. A. Kryzhanovskii.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 1, pp. 54-58, January, 2021

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Kryzhanovskii, S.A., Kozhevnikova, L.M., Vititnova, M.B. et al. On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy. Bull Exp Biol Med 171, 41–44 (2021). https://doi.org/10.1007/s10517-021-05168-6

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  • DOI: https://doi.org/10.1007/s10517-021-05168-6

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