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Beclin-1-Dependent Autophagy of Left Ventricular Cardiomyocytes in SHR and Wistar-Kyoto Rats with Type 1 Diabetes Mellitus

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Autophagy is considered as a mechanism of progression of heart failure, but under certain conditions, it can also act as an adaptation mechanism. Beclin-1 plays the key role in autophagy. We studied the features of Beclin-1 expression in cardiomyocytes of the left ventricle in arterial hypertension, type 1 diabetes mellitus, and their combination. The experiment was performed on male 38-week-old Wistar Kyoto rats and SHR rats aged 38 and 57 weeks. Type 1 diabetes mellitus was modeled by a single parenteral administration of streptozotocin. Expression of Beclin-1 in cardiomyocytes of the left ventricle was evaluated by immunohistochemical analysis. In arterial hypertension, a decrease in the intensity of Beclin-1-dependent autophagy of cardiomyocytes was seen, while in combined pathology, we observed an opposite effect manifested as a significant increase in the expression of protein Beclin-1.

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Authors and Affiliations

  1. V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    M. L. Blagonravov, A. P. Sklifasovskaya, E. A. Demurov & A. A. Karimov

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  1. M. L. Blagonravov
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  2. A. P. Sklifasovskaya
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  3. E. A. Demurov
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  4. A. A. Karimov
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Correspondence to M. L. Blagonravov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 1, pp. 32-37, January, 2021

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Blagonravov, M.L., Sklifasovskaya, A.P., Demurov, E.A. et al. Beclin-1-Dependent Autophagy of Left Ventricular Cardiomyocytes in SHR and Wistar-Kyoto Rats with Type 1 Diabetes Mellitus. Bull Exp Biol Med 171, 23–27 (2021). https://doi.org/10.1007/s10517-021-05164-w

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  • DOI: https://doi.org/10.1007/s10517-021-05164-w

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