Skip to main content
Log in

Expression of Transcription Factor PU.1 in Stromal Cells as a Prognostic Marker in Non-Small Cell Lung Cancer

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Transcription factor PU.1 is involved in hematopoiesis and is expressed in various cells of the inflammatory infiltrate of the tumor stroma, mainly in macrophages. The expression of PU.1 in 100 samples of non-small cell lung cancer was analyzed by the immunohistochemical method. The number of PU.1+ cells did not correlate with clinical and morphological parameters of the tumors. However, increased number of PU.1+ cells significantly correlated with favorable prognosis in adenocarcinoma and poor prognosis in squamous cell carcinoma. Thus, transcription factor PU.1 can serve as a stromal prognostic marker of non-small cell lung cancer depending on the histological type of the tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Iwasaki H, Somoza C, Shigematsu H, Duprez EA, Iwasaki-Arai J, Mizuno S, Arinobu Y, Geary K, Zhang P, Dayaram T, Fenyus ML, Elf S, Chan S, Kastner P, Huettner CS, Murray R, Tenen DG, Akashi K. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005;106(5):1590-1600.

    Article  CAS  Google Scholar 

  2. Li H, Fan X, Houghton J. Tumor microenvironment: the role of the tumor stroma in cancer. J. Cell. Biochem. 2007;101(4):805-815.

    Article  CAS  Google Scholar 

  3. Lin J, Liu W, Luan T, Yuan L, Jiang W, Cai H, Yuan W, Wang Y, Zhang Q, Wang L. High expression of PU.1 is associated with Her-2 and shorter survival in patients with breast cancer. Oncol. Lett. 2017;14(6):8220-8226.

    Google Scholar 

  4. Mak KS, Funnell AP, Pearson RC, Crossley M. PU.1 and haematopoietic cell fate: dosage matters. Int. J. Cell Biol. 2011;2011:808524. doi:

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996;15(20):5647-5658.

    Article  CAS  Google Scholar 

  6. Puderecki M, Szumiło J, Marzec-Kotarska B. Novel prognostic molecular markers in lung cancer. Oncol. Lett. 2020;20(1):9-18.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573-1577.

    Article  CAS  Google Scholar 

  8. Solinas G, Germano G, Mantovani A, Allavena P. Tumorassociated macrophages (TAM) as major players of the cancerrelated inflammation. J. Leukoc. Biol. 2009;86(5):1065-1073.

    Article  CAS  Google Scholar 

  9. Torlakovic EE, Bilalovic N, Golouh R, Zidar A, Angel S. Prognostic significance of PU.1 in follicular lymphoma. J. Pathol. 2006;209(3):352-359.

    Article  CAS  Google Scholar 

  10. Verbiest T, Bouffler S, Nutt SL, Badie C. PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML. Carcinogenesis. 2015;36(4):413-419.

    Article  CAS  Google Scholar 

  11. Xu Y, Gu S, Bi Y, Qi X, Yan Y, Lou M. Transcription factor PU.1 is involved in the progression of glioma. Oncol. Lett. 2018;15(3):3753-3759.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to O. V. Kovaleva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 10, pp. 504-507, October, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kovaleva, O.V., Rashidova, M.A., Samoilova, D.V. et al. Expression of Transcription Factor PU.1 in Stromal Cells as a Prognostic Marker in Non-Small Cell Lung Cancer. Bull Exp Biol Med 170, 489–492 (2021).

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI:

Key Words