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Does the Operation of Mitochondrial ATP-Dependent Potassium Channels Affect the Structural Component of Mitochondrial and Endothelial Dysfunctions in Experimental Parkinsonism?

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

We have previously demonstrated that the development of oxidative stress in some pathologies can be prevented by activation of the mitochondrial ATP-dependent potassium channel (mitoKATP). Here we studied the effect of modulation of mitoKATP on the development of mitochondrial and endothelial dysfunction in the medulla oblongata and myocardium of rats with experimental parkinsonism. It is known that uridine-5’-diphosphate, activator of mitoKATP, does not penetrate the plasma membrane, but it can be synthesized in cells from exogenous uridine that is delivered into cells by special transport systems. Our results suggest that mitoKATP is involved in the development of mitochondrial and endothelial dysfunction in experimental parkinsonism and prove the cardio- and neuroprotective effects of uridine.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, Russia

    A. A. Mosentsov, N. V. Belosludtseva, I. B. Mikheeva & G. D. Mironova

  2. O. O. Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine, Kiev, Ukraine

    E. V. Rozova, I. N. Mankovskaya & Yu. V. Putiy

  3. D. F. Chebotarev State Institute of Gerontology of the National Academy of Sciences of Ukraine, Kiev, Ukraine

    I. N. Karaban

Authors
  1. A. A. Mosentsov
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  2. E. V. Rozova
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  3. N. V. Belosludtseva
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  4. I. N. Mankovskaya
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  5. Yu. V. Putiy
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  6. I. N. Karaban
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  7. I. B. Mikheeva
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  8. G. D. Mironova
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Corresponding author

Correspondence to G. D. Mironova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 10, pp. 437-442, October, 2020

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Mosentsov, A.A., Rozova, E.V., Belosludtseva, N.V. et al. Does the Operation of Mitochondrial ATP-Dependent Potassium Channels Affect the Structural Component of Mitochondrial and Endothelial Dysfunctions in Experimental Parkinsonism?. Bull Exp Biol Med 170, 431–435 (2021). https://doi.org/10.1007/s10517-021-05081-y

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  • DOI: https://doi.org/10.1007/s10517-021-05081-y

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