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Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase (Statins) Suppress Differentiation and Reduce LPS/IFNγ-Induced Cytokine Production in Human Monocyte/Macrophage Culture

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We examined the effects of 72-h exposure to atorvastatin and rosuvastatin in concentrations of 2-10 nM on the cytokine expression in LPS/IFNγ-activated monocyte/macrophages derived from peripheral blood monocytes of healthy donors by culturing in the presence of GM-CSF. Pretreatment with statins was found to inhibit cytokine production in monocytes/macrophages after activation, while the level of cytokine mRNA in cells did not decrease. The number of cells containing active caspase-3 decreased in the culture. Culturing of monocytes/macrophages with statins was accompanied by changes in cell morphology and deceleration of cell growth. Cellular effects of “lipophilic” atorvastastin were observed at lower concentration compared to “hydrophilic” rosuvastatin.

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Authors and Affiliations

  1. National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. Yu. Ruleva, N. V. Radyukhina, E. S. Zubkova, A. Yu. Filatova & T. I. Aref’eva

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  1. N. Yu. Ruleva
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  2. N. V. Radyukhina
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  3. E. S. Zubkova
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  4. A. Yu. Filatova
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  5. T. I. Aref’eva
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Correspondence to N. Yu. Ruleva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 209-214, August, 2020

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Ruleva, N.Y., Radyukhina, N.V., Zubkova, E.S. et al. Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase (Statins) Suppress Differentiation and Reduce LPS/IFNγ-Induced Cytokine Production in Human Monocyte/Macrophage Culture. Bull Exp Biol Med 170, 236–240 (2020). https://doi.org/10.1007/s10517-020-05042-x

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  • DOI: https://doi.org/10.1007/s10517-020-05042-x

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