Skip to main content
SpringerLink
Log in

Changes in the Biorhythms of Biochemical Parameters in Animals with Modeled Acute Desynchronosis

  • BIOPHYSICS AND BIOCHEMISTRY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

This article describes models for the study of acute desynchronosis: jetlag syndrome and acute desynchronosis under physical stress for possible pharmacological correction of these disorders. The cosinor analysis allowed assessing significance of changes in biological rhythms in 2 biological models: the jetlag-type diurnal rhythm shift model and the model with changed light mode. The revealed changes in the rhythms of biochemical parameters in the blood serum of animals with acute desynchronosis indicate significant changes in the intensity of carbohydrate-lipid metabolism, which affected the processes of cell bioenergetics. These changes are most pronounced in the group of animals that were kept under conditions of constant darkness, which can serve as a marker of the initial stage of pathological desynchronosis. The jetlag-type model can be used to evaluate the effectiveness of the pharmacological correction of physiological desynchronosis. The model with modified light regimen can be used for evaluation of the effectiveness of pharmacological correction of pathological desynchronosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Batotsyrenova EG. The influence of disbalance light conditions on the parameters of acid-base balance after intensive physical exercise. Medline.ru. Ross. Biomed. Zh. 2018;19(4):1204- 1216. Russian.

    Google Scholar 

  2. Batotsyrenova EG, Kashuro VA, Ivanov MB. Markers of energy metabolism in destabilization of circadian rhythms. Vopr. Biol., Med. Farm. Khimii. 2017;20(11):39-42. Russian.

    Google Scholar 

  3. Batotsyrenova EG, Kashuro VA, Ivanov MB, Stepanov SV, Skomorokhova EB. Change in the indicators of energy metabolism under condition of desynchronosis. Acta Naturae. 2016;(Suppl. 1):182-186. Russian.

  4. Karp VP, Katinas GS. Mathematical methods of analysis of biological rhythms. Chronobiology and chronomedicine. Moscow, 1989. P. 29-45. Russian.

  5. Chronobiology and chronomedicine. Rapoport SI, Frolov VA, Khetagurova LG, eds. Moscow, 2012. Russian.

    Google Scholar 

  6. Eckel-Mahan K, Sassone-Corsi P. Metabolism control by the circadian clock and vice versa. Nat. Struct. Mol. Biol. 2009;16(5):462-467. doi: https://doi.org/10.1038/nsmb.1595

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gao S, Casals N, Keung W, Moran TH, Lopaschuk GD. Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei. Physiol. Behav. 2013;118:165-70. doi: https://doi.org/10.1016/j.physbeh.2013.03.030

    Article  CAS  PubMed  Google Scholar 

  8. Green CB, Takahashi JS, Bass J. The meter of metabolism. Cell. 2008;134(5):728-742. doi: https://doi.org/10.1016/j.cell.2008.08.022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM. Interacting molecular loops in the mammalian circadian clock. Science. 2000;288:1013-1019.

    Article  CAS  Google Scholar 

  10. Taïb B, Bouyakdan K, Hryhorczuk C, Rodaros D, Fulton S, Alquier T. Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes. J. Biol. Chem. 2013;288(52):37 216-37 229. doi: https://doi.org/10.1074/jbc.M113.506238

  11. Tseng HL, Yang SC, Yang SH, Shieh KR. Hepatic circadianclock system altered by insulin resistance, diabetes and insulin sensitizer in mice. PLoS One. 2015;10(3). e0120380. doi: https://doi.org/10.1371/journal.pone.0120380

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Zeng L, Ming C, Li Y, Su LY, Su YH, Otecko NO, Liu HQ, Wang MS, Yao YG, Li HP, Wu DD, Zhang YP. Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat. Mol. Biol. Evol. 2017;34(12):3148-3153. doi: https://doi.org/10.1093/molbev/msx238

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia

    E. G. Batotsyrenova, M. B. Ivanov, V. A. Kashuro, E. A. Zolotoverkhaja, T. A. Kostrova & A. V. Sharabanov

  2. P. F. Lesgaft National State University of Physical Education, Sport and Health, St. Petersburg, Russia

    S. E. Bakulev & T. G. Nevzorova

  3. St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    E. G. Batotsyrenova

Authors
  1. E. G. Batotsyrenova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. E. Bakulev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. G. Nevzorova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. B. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. A. Kashuro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. A. Zolotoverkhaja
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. A. Kostrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. V. Sharabanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. G. Batotsyrenova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 155-159, August, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Batotsyrenova, E.G., Bakulev, S.E., Nevzorova, T.G. et al. Changes in the Biorhythms of Biochemical Parameters in Animals with Modeled Acute Desynchronosis. Bull Exp Biol Med 170, 191–195 (2020). https://doi.org/10.1007/s10517-020-05030-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-05030-1

Key Words

Search

Navigation