Skip to main content

Advertisement

SpringerLink
Log in

Bilirubin in the Vitreous Body of the Eye of Human Fetuses

  • EXPERIMENTAL BIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The bilirubin content in the vitreous body of the eye of human fetuses of gestation week 17-31 was measured. During gestation weeks 17-19, the mean bilirubin concentration was 8.67 μmol/liter; then, decreased to 1.37 μmol/liter (gestation weeks 20 to 31). Bilirubin, being an endogenous antioxidant, is probably involved in protection of the retina and lens from LPO processes that intensively develop in retinal neurons and lens fibers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Doré S, Takahashi M, Ferris CD, Zakhary R, Hester LD, Guastella D, Snyder SH. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc. Natl Acad. Sci. USA. 1999;96(5):2445-2450.

    Article  Google Scholar 

  2. Kurzel RB, Heinrikson RL. On the presence of bilirubin in the ocular humors of premature infants. Invest. Ophthalmol. 1976;15(6):509-512.

    CAS  PubMed  Google Scholar 

  3. Le Goff MM, Bishop PN. Adult vitreous structure and postnatal changes. Eye (Lond). 2008;22(10):1214-1222. https://doi.org/10.1038/eye.2008.21

    Article  PubMed  Google Scholar 

  4. Liu Y, Li P, Lu J, Xiong W, Oger J, Tetzlaff W, Cynader M. Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis. J. Immunol. 2008;181(3):1887-1897.

    Article  CAS  Google Scholar 

  5. Lovicu FJ, McAvoy JW. Growth factor regulation of lens development. Dev. Biol. 2005;280(1):1-14.

    Article  CAS  Google Scholar 

  6. Naumann HN, Young JM. Comparative bilirubin levels in vitreous body, synovial fluid, cerebrospinal fluid and serum after death. Proc. Soc. Exp. Biol. Med. 1960;105:70-72.

    Article  CAS  Google Scholar 

  7. Panova IG, Tatikolov AS. Investigation of the content of alpha-fetoprotein and serum albumin in the vitreous body of the eye of human embryos. Biol. Bull. 2011;38(2):191-194. https://doi.org/10.1134/S1062359011020105

    Article  CAS  Google Scholar 

  8. Panova IG, Yakovleva MA, Tatikolov AS, Kononikhin AS, Feldman TB, Poltavtseva RA, Nikolaev EN, Sukhikh GT, Ostrovsky MA. Lutein and its oxidized forms in eye structures throughout prenatal human development. Exp. Eye Res. 2017;160:31-37. https://doi.org/10.1016/j.exer.2017.04.008

    Article  CAS  PubMed  Google Scholar 

  9. Provis JM, Penfold PL, Cornish EE, Sandercoe TM, Madigan MC. Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration. Clin. Exp. Optom. 2005;88(5):269-281.

    Article  Google Scholar 

  10. Sedlak TW, Snyder SH. Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics. 2004;113(6):1776-1782.

    Article  Google Scholar 

  11. Usman F, Diala UM, Shapiro SM, Le Pichon JB, Slusher TM. Acute bilirubin encephalopathy and its progression to kernicterus: current perspectives. Res. Reports Neonatology. 2018;8:33-44. https://doi.org/10.2147/RRN.S125758

    Article  Google Scholar 

  12. Vítek L, Ostrow JD. Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects. Curr. Pharm. Des. 2009;15(25):2869-2883. https://doi.org/10.2174/138161209789058237

    Article  PubMed  Google Scholar 

  13. Weiner CP. Human fetal bilirubin levels and fetal hemolytic disease. Am. J. Obstet. Gynecol. 1992;166(5):1449-1454.

    Article  CAS  Google Scholar 

  14. Yee KM, Feener EP, Madigan M, Jackson NJ, Gao BB, Ross-Cisneros FN, Provis J, Aiello LP, Sadun AA, Sebag J. Proteomic Analysis of Embryonic and Young Human Vitreous. Invest. Ophthalmol. Vis. Sci. 2015;56(12):7036-7042. https://doi.org/10.1167/iovs.15-16809

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Zhu M, Madigan MC, van Driel D, Maslim J, Billson FA, Provis JM, Penfold PL. The human hyaloid system: cell death and vascular regression. Exp. Eye Res. 2000;70(6):767-776.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    I. G. Panova

  2. V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    Yu. V. Sukhova & T. Yu. Ivanets

  3. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. S. Tatikolov

Authors
  1. I. G. Panova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu. V. Sukhova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. S. Tatikolov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Yu. Ivanets
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. G. Panova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 118-120, July, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Panova, I.G., Sukhova, Y.V., Tatikolov, A.S. et al. Bilirubin in the Vitreous Body of the Eye of Human Fetuses. Bull Exp Biol Med 170, 98–100 (2020). https://doi.org/10.1007/s10517-020-05012-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-05012-3

Key Words

Search

Navigation