The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with dissemination of gastric cancer. An increase in the mRNA level of all components of this cascade was demonstrated. The expression of mTOR and AKT decreased against the background of enhanced expression of PTEN phosphatase. The increase in the expression of PD-1 receptors and PD-L1 and PD-L2 ligands was most pronounced in patients with distant metastases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Spirina LV, Chizhevskaya SYu, Kondakova IV, Tarasenko NV. The role of autophagy in the thyroid tumors development, connection with the AKT/M-TOR signaling pathway activation. Klin. Eksp. Tireoidol. 2019;15(3):110-117. Russian.
Guri Y, Nordmann T.M, Roszik J. mTOR at the Transmitting and Receiving Ends in Tumor Immunity. Front. Immunol. 2018;9. ID 578. doi: 0.3389/fimmu.2018.00578
Kim LC, Cook RS, Chen J. mTORC1 and mTORC2 in cancer and the tumor microenvironment. Oncogene. 2017;36(16): 2191-2201.
Murakami D, Tsujitani S, Osaki T, Saito H, Katano K, Tatebe S, Ikeguchi M. Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy. Gastric Cancer. 2007;10(1):45-51.
Sasaki T, Kuniyasu H. Significance of AKT in gastric cancer (Review). Int. J. Oncol. 2014;45(6):2187-2192.
Spirina LV, Kondakova IV, Tarasenko NV, Slonimskaya EM, Usynin EA, Gorbunov AK, Yurmazov ZA, Chigevskaya SY. Targeting of the AKT/m-TOR pathway: biomarkers of resistance to cancer therapy — AKT/m-TOR pathway and resistance to cancer therapy. Zhongguo Fei Ai Za Zhi. 2018;21(1):63-66.
Tapia O, Riquelme I, Leal P, Sandoval A, Aedo S, Weber H, Letelier P, Bellolio E, Villaseca M, Garcia P, Roa JC. The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance. Virchows Arch. 2014;465(1):25-33.
Yang L, Huang F, Mei J, Wang X, Zhang Q, Wang H, Xi M, You Z. Posttranscriptional control of PD-L1 expression by 17β-estradiol via PI3K/Akt signaling pathway in ERα-positive cancer cell lines. Int. J. Gynecol. Cancer. 2017;27(2):196-205.
Zhao C, Tao T, Yang L, Qin Q, Wang Y, Liu H, Song R, Yang X, Wang Q, Gu S, Xiong Y, Zhao D, Wang S, Feng D, Jiang W.G, Zhang J, He J. Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer. Cancer Lett. 2019;453:107-121.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 91-95, July, 2020
Rights and permissions
About this article
Cite this article
Spirina, L.V., Avgustinovich, A.V., Afanas’ev, S.G. et al. AKT/mTOR Signal Cascade and Expression of PD-1, PD-L1, and PD-L2 in Gastric Cancer. Bull Exp Biol Med 170, 75–78 (2020). https://doi.org/10.1007/s10517-020-05007-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-020-05007-0