Inflammation Mediators Regulate the Microbiota Resistance to Adverse Factors

We studied the effects of IL-1β, IL-8, TNFα, and prostaglandin E2α in concentrations typically observed in health and during inflammation on the growth of vaginal microbiota and its resistance to factors inhibiting the synthesis of proteins, nucleic acids, and peptidoglycans. An increase in the cytokine levels, characteristic of inflammation, inhibits the growth of Lactobacillus population and improves its resistance to adverse factors. The growth of the population of opportunistic microorganisms (S. aureus, E. coli) is stimulated under these conditions, while their resistance to adverse factors decreases. Hence, it seems that the cytokines regulate the behavior of the host cells and of its bacterial symbionts.

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References

  1. 1.

    Sgibnev AV, Kremleva EA. Vaginal lactobacilli regulate the activity of muramidase via hydrogen peroxide and surfactants. Zh. Mikrobiol., Epidemiol., Epidemiol. 2018;(4):21-27. Russian.

  2. 2.

    Carrillo W, García-Ruiz A, Recio I, Moreno-Arribas MV. Antibacterial activity of hen egg white lysozyme modified by heat and enzymatic treatments against oenological lactic acid bacteria and acetic acid bacteria. J. Food Prot. 2014;77(10):1732-1739.

    CAS  Article  Google Scholar 

  3. 3.

    Högbom M, Ihalin R. Functional and structural characteristics of bacterial proteins that bind host cytokines. Virulence. 2017;8(8):1592-1601.

    Article  Google Scholar 

  4. 4.

    Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454):428-435.

    CAS  Article  Google Scholar 

  5. 5.

    Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard — Seventh edition. Clinical and Laboratory Standards Institute, 2006. Vol. 26, No. 2.

  6. 6.

    Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 2005;6(12):1191-1197.

    CAS  Article  Google Scholar 

Download references

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Correspondence to A. V. Sgibnev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 61-65, July, 2020

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Sgibnev, A.V., Kremleva, E.A. Inflammation Mediators Regulate the Microbiota Resistance to Adverse Factors. Bull Exp Biol Med 170, 49–52 (2020). https://doi.org/10.1007/s10517-020-05002-5

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Key Words

  • inflammation
  • lactobacilli
  • interspecies communication
  • resistance
  • cytokines