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Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes

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Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical analysis showed that the decrease in the number of β cells and a violation of their morphological structure caused by STZ were significantly alleviated by Afobazole administration (10 mg/kg orally for 28 days) to diabetic animals. A correlation between morphometric data and blood glucose level was revealed. A possible role of σ1-receptors in the cytoprotective effects of Afobazole in respect to pancreatic β cells is discussed.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    S. V. Ivanov, R. U. Ostrovskaya, A. V. Sorokina & S. B. Seredenin

Authors
  1. S. V. Ivanov
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  2. R. U. Ostrovskaya
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  3. A. V. Sorokina
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  4. S. B. Seredenin
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Corresponding author

Correspondence to R. U. Ostrovskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 727-731, June, 2020

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Ivanov, S.V., Ostrovskaya, R.U., Sorokina, A.V. et al. Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes. Bull Exp Biol Med 169, 783–786 (2020). https://doi.org/10.1007/s10517-020-04978-4

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  • DOI: https://doi.org/10.1007/s10517-020-04978-4

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