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Thromboelastographic Research of Arginine-, Leucine and Lysine-Containing Peptides

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Anticoagulant effects of 12 short peptides of the glyproline series — Arg-Glu-Arg-Pro-Gly-Pro (RERPGP), Arg-Glu-Arg-Val-Gly-Pro (RERVGP), Arg-Glu-Arg-Gly-Pro (RERGP), Arg-Pro-Gly-Pro (RPGP), Pro-Leu-Pro (PLP), Pro-Leu-Pro-Ala (PLPA), Pro-Gly-Pro-Leu (PGPL), Phe-Pro-Leu-Pro-Ala (FPLPA), Pyr-Arg-Pro (PyrRP), Lys-Lys-Arg-Arg-Pro-Gly-Pro (KKRRPGP), Arg-Lys-Lys-Arg-Pro-Gly-Pro (RKKRPGP), and Lys-Arg-Lys-Pro-Gly-Pro (KRKPGP) in concentrations of 10—3 and 10—2 mg/ml in vitro was demonstrated by the thromboelastographic method. The effects of 6 peptides ((RERPGP, RPGP, PLP, PLPA, RKKRPGP, and KKRRPGP) were also observed in vivo after intranasal or oral administration. Changes in the studied thromboelastographic parameters towards hypocoagulation in comparison with the control group were noted. Arginine and leucine glyprolines produced the maximum anticoagulant effect.

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Authors and Affiliations

  1. Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    E. Ya. Rogozinskaya, L. A. Lyapina, T. A. Shubina, M. E. Grigorieva & T. Yu. Obergan

  2. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    N. F. Myasoedov & L. A. Andreeva

Authors
  1. E. Ya. Rogozinskaya
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  2. L. A. Lyapina
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  3. T. A. Shubina
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  4. N. F. Myasoedov
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  5. M. E. Grigorieva
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  6. T. Yu. Obergan
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  7. L. A. Andreeva
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Correspondence to E. Ya. Rogozinskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 716-719, June, 2020

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Rogozinskaya, E.Y., Lyapina, L.A., Shubina, T.A. et al. Thromboelastographic Research of Arginine-, Leucine and Lysine-Containing Peptides. Bull Exp Biol Med 169, 775–777 (2020). https://doi.org/10.1007/s10517-020-04976-6

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  • DOI: https://doi.org/10.1007/s10517-020-04976-6

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