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Role of β3-Adrenoceptor Activation in Changes of Pulmonary Microhemodynamics after Experimental Pulmonary Thromboembolism

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Changes in pulmonary microhemodynamics during modelling of pulmonary thromboembolism against the background of nebivolol and mirabegron pretreatment were studied in isolated perfused rabbit lungs. In both cases, the pulmonary artery pressure and precapillary and pulmonary vascular resistance increased to a greater extent than in control animals, but the increase in capillary hydrostatic pressure was less pronounced. The postcapillary resistance did not change in pulmonary embolism against the background of nebivolol administration and increased in case of mirabegron pretreatment; capillary filtration coefficient after nebivolol pretreatment increased less markedly than after mirabegron administration. The increase in capillary filtration coefficient after activation of β3-adrenoceptors with the specified drugs depended on the ratio of constriction of pulmonary veins, capillary hydrostatic pressure, and endothelial permeability.

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Authors and Affiliations

  1. Laboratory of Physiology of the Visceral Systems, Institute of the Experimental Medicine, St. Petersburg, Russia

    V. I. Evlakhov, T. P. Berezina & I. Z. Poyassov

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  1. V. I. Evlakhov
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  2. T. P. Berezina
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  3. I. Z. Poyassov
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Correspondence to V. I. Evlakhov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 691-694, June, 2020

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Evlakhov, V.I., Berezina, T.P. & Poyassov, I.Z. Role of β3-Adrenoceptor Activation in Changes of Pulmonary Microhemodynamics after Experimental Pulmonary Thromboembolism. Bull Exp Biol Med 169, 751–754 (2020). https://doi.org/10.1007/s10517-020-04971-x

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  • DOI: https://doi.org/10.1007/s10517-020-04971-x

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