Skip to main content
SpringerLink
Log in

Effect of Humic Acids from Lowland Peat on Endurance of Rats in Forced Swim Test in Relation to Serum Lactate and Corticosterone

  • GENERAL PATHOLOGY AND PATHOLOGICAL PHYSIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The study substantiated the possibility of using peat humic acids for improving endurance during extreme physical exertion. The mature outbred Wistar rats weighing 200-250 g (n=40) were subjected to forced swim test until complete exhaustion. The humic acids (1%) were administered intragastrically (0.5 ml/100 g body weight) 30 min prior to the test. Chronic administration of peat humic acids for 5 days increased physical capacity and endurance of rats in exhaustive forced swim test without the changes in serum lactate and corticosterone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bambalov NN. Use of peat as an organic raw material for chemical processing. Solid Fuel Chemistry. 2012;46(5):282-288.

    CAS  Google Scholar 

  2. Buzlama AV, Chernov UN. Humic substances: pharmacological properties, mechanisms of action, and prospects for use in medicine. Eksp. Klin. Farmakol. 2010;73(9):43-48. Russian.

    CAS  PubMed  Google Scholar 

  3. Gostyukhina AA, Zaitsev KV, Zamoshchina TA, Zhukova OB, Svetlik MV, Abdulkina NG. Seasonal features of corticosterone blood serum of rats after physical overwork under desynchronosis. Ross. Fiziol. Zh. 2016;102(1):50-55. Russian.

    CAS  Google Scholar 

  4. Gostyukhina AA, Zamoshchina TA, Zaitsev KV, Zhukova OB, Gutor SS, Svetlik MV, Abdulkina NG, Zaitsev AA. Adaptive reactions of rats after light desynchronosis and physical overwork. Byull. Sib. Med. 2018;17(3):22-34. Russian.

    Google Scholar 

  5. Gostyukhina AA, Zamoshchina TA, Zaitsev KV, Zhukova OB, Svetlik MV, Abdulkina NG, Zaitsev AA. Effects of light or dark deprivation on performance and lactate levels in rat blood. Ross. Fiziol. Zh. 2016;102(5):584-589. Russian.

    CAS  Google Scholar 

  6. Zykova MV, Balousov MV, Gur’ev AM, Akhmedzhanov RR, Yusubov MS. Standardization of humic acids of lowland wood-grass peat from tomsk region. Khim.-Farm. Zh. 2013;47(12):53-56. Russian.

    Google Scholar 

  7. Meerson FZ, Pshennikova MG. Adaptation to Stress Situation and Physical Load. Moscow, 1988. Russian.

    Google Scholar 

  8. Zykova MV, Danilets MG, Krivoshchekov SV, Trofimova ES, Ligacheva AA, Sherstoboev EY, Belousov MV, Yusubov MS. Patent RU No. 2610446. Preparation, increasing production of nitrogen oxide by macrophages in vitro, based on humic acids of peat of Tomsk region bogs and method for obtaining thereof. Bull. No. 4. Published February 13, 2017.

  9. Gostyukhina AA, Zajtsev KV, Zamoshchina TA, Svetlik MV, Zhukova OB, Abdulkina NG, Zajtsev AA, Vorobev VA. Patent RU No. 2617206. Method for physical fatigue simulation in rats under desynchronosis. Bull. No. 5. Published April 21, 2017.

  10. Perminova IV. Humic substances-a challenge to chemists of the XXI century. Khimiya Zhiz’n’. 2008;(1):50-55. Russian.

    Google Scholar 

  11. Peña-Méndez EM, Havel J, Patočka J. Humic substances - compounds of still unknown structure: applications in agriculture, industry, environment, and biomedicine. J. Appl. Biomed. 2005;3(1):13-24. doi: https://doi.org/10.32725/jab.2005.002

    Article  Google Scholar 

  12. Radomska-Leśniewska DM, Skopińska-Różewska E, Jóźwiak J, Demkow U, Joanna Bałan B. Angiomodulatory properties of some antibiotics and Tołpa Peat Preparation. Cent. Eur. J. Immunol. 2016;41(1):19-24. doi: https://doi.org/10.5114/ceji.2016.58312

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Vašková J, Veliká B, Pilátová M, Kron I, Vaško L. Effects of humic acids in vitro. In Vitro Cell. Dev. Biol. Anim. 2011;47(5-6):376-382. doi: https://doi.org/10.1007/s11626-011-9405-8

    Article  CAS  PubMed  Google Scholar 

  14. Zykova MV, Schepetkin IA, Belousov MV, Krivoshchekov SV, Logvinova LA, Bratishko KA, Yusubov MS, Romanenko SV, Quinn MT. Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins. Molecules. 2018;23(4). pii: E753. doi: https://doi.org/10.3390/molecules23040753

Download references

Author information

Authors and Affiliations

  1. Siberian Federal Scientific and Clinical Center, Federal Medical-Biological Agency of Russia, Seversk, Russia

    T. A. Zamoshchina, A. A. Gostyukhina, K. V. Zaitsev & N. G. Abdulkina

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    T. A. Zamoshchina, M. V. Zykova, L. A. Logvinova, M. V. Svetlik, E. A. Kurtsevich & M. V. Belousov

  3. Tomsk State Pedagogical University, Tomsk, Russia

    T. V. Lasukova

  4. Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    T. V. Lasukova

  5. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    A. M. Dygai

Authors
  1. T. A. Zamoshchina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. V. Zykova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Gostyukhina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. A. Logvinova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. V. Zaitsev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. V. Lasukova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. V. Svetlik
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. A. Kurtsevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. N. G. Abdulkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. V. Belousov
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. A. M. Dygai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. V. Zaitsev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 673-676, June, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zamoshchina, T.A., Zykova, M.V., Gostyukhina, A.A. et al. Effect of Humic Acids from Lowland Peat on Endurance of Rats in Forced Swim Test in Relation to Serum Lactate and Corticosterone. Bull Exp Biol Med 169, 734–737 (2020). https://doi.org/10.1007/s10517-020-04967-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-04967-7

Key Words

Search

Navigation