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A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We analyzed biodistribution of 68Ga-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in Wistar rats with experimental model of bone callus. It was shown that the content of 68Ga-DTPMP and 68Ga-HEDP in bone callus was ~1.5-fold higher than in intact femur. 68Ga-DTPMP was characterized by higher stability in vivo, higher uptake in the bone tissue, and lower uptake in others visceral organs in comparison with 68Ga-HEDP. Thus, 68Ga-DTPMP had more suitable pharmacokinetic properties than 68Ga-HEDP.

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Authors and Affiliations

  1. National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia

    V. K. Tishchenko, V. M. Petriev, K. A. Kuzenkova, P. V. Shegai, S. A. Ivanov & A. D. Kaprin

  2. National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia

    V. K. Tishchenko & V. M. Petriev

Authors
  1. V. K. Tishchenko
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  2. V. M. Petriev
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  3. K. A. Kuzenkova
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  4. P. V. Shegai
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  5. S. A. Ivanov
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  6. A. D. Kaprin
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Corresponding author

Correspondence to V. K. Tishchenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 573-577, May, 2020

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Tishchenko, V.K., Petriev, V.M., Kuzenkova, K.A. et al. A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus. Bull Exp Biol Med 169, 644–647 (2020). https://doi.org/10.1007/s10517-020-04945-z

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  • DOI: https://doi.org/10.1007/s10517-020-04945-z

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