Skip to main content

Advertisement

Log in

Influence of Fucoxanthin on Proliferative Activity of Human Melanocyte Culture

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of algae pigment fucoxanthin on proliferative activity of melanocyte culture from human skin. Fucoxanthin in high concentrations can be cytotoxic, which was confirmed by changes in melanocyte morphology and a decrease in their proliferative activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kozhina KV, Volkova EN, Saburina IM, Morozov SG, Zurina IM, Kosheleva NV, Gorkun AA, Grigor’eva AA. Meso-Wharton P199™: experimental substantiation of the mechanisms of anti-age effect of the drug on models of dermal fibroblast cultures. Metamorfozy. 2016;(13):64-70. Russian.

    Google Scholar 

  2. Kozhina KV, Saburina IN, Gorkun AA, Zurina IN, Kosheleva NV, Volkova EN, Morozov SG. Copmarative study of p199 effect on 2D and 3D cultures of human dermal fibroblasts. Patogenez. 2015;13(4):34-40. Russian.

    Google Scholar 

  3. Saburina IN, Dzussoeva EV, Gorkun AA, Zurina IM, Kosheleva NV, Kolokol’tseva TD, Skuratovskaya LN, Repin VS. 3D culture of melanocytes as a test system and cell model for studying melanogenesis pathology. Patol. Fiziol. Ekp. Ter. 2018;62(4):265-268. Russian.

    Google Scholar 

  4. Human Epidermal Melanocytes: HEM Cell Applications Inc, Brochure. URL: https://www.cellapplications.com/human-epidermal-melanocytes-hem

  5. Mei C, Zhou S, Zhu L, Ming J, Zeng F, Xu R. Antitumor effects of Laminaria extract fucoxanthin on lung cancer. Mar. Drugs. 2017;15(2):E39. doi: https://doi.org/10.3390/md15020039

    Article  CAS  PubMed  Google Scholar 

  6. Nazih H, Bard JM. Microalgae in human health: interest as a functional food. Microalgae in Health and Disease Prevention. Levine IA, Fleurence J, eds. Academic Press. 2018. P. 211-226.

    Book  Google Scholar 

  7. Peng J, Yuan JP, Wu CF, Wang JH. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar. Drugs. 2011;9(10):1806-1828.

    Article  CAS  Google Scholar 

  8. Rwigemera A, Mamelona J, Martin LJ. Comparative effects between fucoxanthinol and its precursor fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231. Anticancer Res. 2015;35(1):207-219.

    CAS  PubMed  Google Scholar 

  9. Rwigemera A, Mamelona J, Martin LJ. Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway. Cell Biol. Toxicol. 2014;30(3):157-167.

    Article  CAS  Google Scholar 

  10. Sagrillo-Fagundes L, Clabault H, Laurent L, Hudon-Thibeault AA, Salustiano EM, Fortier M, Bienvenue-Pariseault J, Wong Yen P, Sanderson JT, Vaillancourt C. Human primary trophoblast cell culture model to study the protective effects of melatonin against hypoxia/reoxygenation-induced disruption. J. Vis. Exp. 2016;(113). doi: https://doi.org/10.3791/54228

  11. Takahashi K, Hosokawa M, Kasajima H, Hatanaka K, Kudo K, Shimoyama N, Miyashita K. Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues. Oncol. Lett. 2015;10(3):1463-1467.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. D. Kolokol’tsova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 139-142, June, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dzhussoeva, E.V., Gorkun, A.A., Zurina, I.M. et al. Influence of Fucoxanthin on Proliferative Activity of Human Melanocyte Culture. Bull Exp Biol Med 169, 596–599 (2020). https://doi.org/10.1007/s10517-020-04935-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-04935-1

Key Words

Navigation