We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress. Semax was injected to Wistar male rats intraperitoneally in doses of 5, 50, 150, 450 μg/kg 12-15 min before modelling chronic restraint stress. It was found that stress exposure reduced the number of obligate bacteria in the colon microbiota, but increased the content of opportunistic microorganisms. Semax in doses of 50 and 150 μg/kg prevented the stress-induced changes in the composition of colon microbiota. The observed effects of Semax might be mediated by the central neurotropic effects as well as by binding to peripheral melanocortin receptors of the intestine.
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Bogdanova YeA, Nesvizhsky YuV, Vorobyov AA, Afanasyev SS, Korneyev ML. A study of parietal gastroint-eatinal microflora of rats after oral administration of probiotics. Vestn. Ross. Akad. Med. Nauk. 2006;(2):6-10. Russian.
Levitskaya NG, Glazova NYu, Sebentsova EA, Manchenko DM, Vilenskii DA, Andreeva LA, Kamenskii AA, Myasoedov NF. The spectrum of physiological activity of the analogue AKTG4-10 heptapeptide semaks. Neirokhimiya. 2008;25(1):111-118.
Manchenko DM, Glazova NYu, Levitskaya NG, Andreeva LA, Kamensky AA, Myasoedov NF. Nootropic and analgesic effects of Semax following different routes of administration. Ross. Fiziol. Zh. 2010;96(10):1014-1023. Russian.
Pravdivtseva MI, Karpunina LV, Smetanina MD. Effect of exopolysaccharides of Lactobacill on the microflora of large intestine in female rats at various kinds of stress. Izv. Saratov. Univer. 2011;11(2):89-94.
Romanova GA, Silachev DN, Shakova FM, Kvashennikova YN, Viktorov IV, Shram SI, Myasoedov NF. Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex. Bull. Exp. Biol. Med. 2006;142(6):663-666.
Samotrueva MA, Yasenyavskaya AL, Murtalieva VK, Bashkina OA, Myasoedov NF, Andreeva LA, Karaulov AV. Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress. Bull. Exp. Biol. Med. 2019;166(6):754-758. https://doi.org/10.1007/s10517-019-04434-y
Crumeyrolle-Arias M, Jaglin M, Bruneau A, Vancassel S, Cardona A, Daugé V, Naudon L, Rabot S. Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats. Psychoneuroendocrinology. 2014;42:207-217.
Dinan TG, Cryan JF. Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology. Psychoneuroendocrinology. 2012;37(9):1369-1378.
Kim MH, Leem YH. Chronic exercise improves repeated restraint stress-induced anxiety and depression through 5HT1A receptor and cAMP signaling in hippocampus. J. Exerc. Nutrition Biochem. 2014;18(1):97-104.
Stilling RM, Dinan TG, Cryan JF. Microbial genes, brain & behaviour — epigenetic regulation of the gut-brain axis. Genes Brain Behav. 2014;13(1):69-86.
Wikberg JE, Muceniece R, Mandrika I, Prusis P, Lindblom J, Post C, Skottner A. New aspects on the melanocortins and their receptors. Pharmacol. Res. 2000;42(5):393-420.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 330-333, March, 2020
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Svishcheva, M.V., Mukhina, A.Y., Medvedeva, O.A. et al. Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress. Bull Exp Biol Med 169, 357–360 (2020). https://doi.org/10.1007/s10517-020-04886-7
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DOI: https://doi.org/10.1007/s10517-020-04886-7