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Formation of the Resistance of Campylobacter jejuni to Macrolide Antibiotics

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The tendency to the formation of macrolide resistance in campylobacteriosis pathogens is considered as a serious threat to public health due to ubiquity of campylobacter strains resistant to a wide range of antibiotics, primarily fluoroquinolones and tetracyclines. To assess the prevalence of resistant Campylobacter spp., we performed screening for macrolide sensitivity among 40 Campylobacter jejuni strains isolated from raw milk, poultry product, and washings from the equipment of the poultry processing plants. Phenotypic resistance to erythromycin, the most popular antibiotic for the treatment of campylobacteriosis, was revealed in 27.5% C. jejuni strains; 10% strains were resistant to azithromycin. The search and selection for gene markers of Campylobacter resistance to macrolides was performed. It was found that the resistance of C. jejuni to erythromycin is realized mainly via synthesis of proteins that protect ribosomes (the presence of coding sequences was detected in 45% of the studied strains) and the transmembrane pump mechanism (efflux pump CmeABC genes were found in 36% isolates); both mechanisms are transmissible. Chromosomal mutations in the 23S rRNA sequence detected in 18% strains seem to play a less significant role.

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Authors and Affiliations

  1. Federal Research Center of Nutrition and Biotechnology, Moscow, Russia

    N. R. Efimochkina, V. V. Stetsenko & S. A. Sheveleva

Authors
  1. N. R. Efimochkina
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  2. V. V. Stetsenko
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  3. S. A. Sheveleva
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Correspondence to N. R. Efimochkina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 324-329, March, 2020

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Efimochkina, N.R., Stetsenko, V.V. & Sheveleva, S.A. Formation of the Resistance of Campylobacter jejuni to Macrolide Antibiotics. Bull Exp Biol Med 169, 351–356 (2020). https://doi.org/10.1007/s10517-020-04885-8

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  • DOI: https://doi.org/10.1007/s10517-020-04885-8

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