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Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29

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Hepatocellular carcinoma is characterized by the pronounced vascularization, high levels of vascular endothelial growth factors, and intensive angiogenesis. Caveola-mediated endocytosis and clathrin-dependent endocytosis contribute to internalization of various growth factors, thus affecting blood supply to the tumor and neoangiogenesis. We performed a quantitative analysis of blood vessels in the tumor and evaluated the basal levels of endocytosis-associated vesicular structures in the endothelial cells of the hepatocellular carcinoma-29. The numbers of blood vessels and clathrin-coated vesicles in endothelial cells in the tumor tissue were significantly higher than in normal tissue. The association between clathrin-dependent endocytosis in the endotheliocytes of the capillaries and tumor angiogenesis can provide the basis for the development of new molecular targets for antiangiogenic antitumor therapy.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    Yu. S. Taskaeva, V. V. Makarova, I. S. Gogaeva & N. P. Bgatova

  2. Novosibirsk National Research State University, Novosibirsk, Russia

    Yu. S. Taskaeva & I. S. Gogaeva

Authors
  1. Yu. S. Taskaeva
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  2. V. V. Makarova
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  3. I. S. Gogaeva
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  4. N. P. Bgatova
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Correspondence to Yu. S. Taskaeva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 2, pp. 242-246, February, 2020

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Taskaeva, Y.S., Makarova, V.V., Gogaeva, I.S. et al. Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29. Bull Exp Biol Med 169, 276–280 (2020). https://doi.org/10.1007/s10517-020-04867-w

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  • DOI: https://doi.org/10.1007/s10517-020-04867-w

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