Mauthner neurons in goldfish fry were studied by the methods of light and electron microscopy. The structure and volume of individual dendrites as well as the structure of axodendritic synapses were examined using virtual images of neurons formed from serial 3-μ sections. In short-time (5 h) experiments with application of dopamine, β-amyloid fragment (25-35), and long-term sensory stimulation affecting afferent inputs to Mauthner neurons, the dendrites were larger than the same dendrites under the same conditions without dopamine application. Application of dopamine induced no pathological changes in the structure of axodendritic chemical and electric synapses containing desmosome-like contacts.
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Mikhailova GZ, Kokanova NA, Tiras NR, Moshkov DA. Three-Dimensional Reconstruction and Volume Determination of Neurons. Moscow, 2012. Russian.
Moshkov DA, Pavlik LL, Shubina VS, Parnyshkova EY, Mikheeva IB. Cytoskeletal regulation of the cellular function by dopamine. Biophysics. 2010;55(5):750-755.
Pavlik LL, Tiras NR, Mukhtasimova NF, Pakhotin PI, Dzeban DA, Moshkov DA. Involvement of actin in electrotonic transmission of mixed synapses of Mauthner neurons of goldfish. Morfologiya. 2003;123(1):41-45. Russian.
Tiras NR, Mikheyeva IB, Mikhailova GZ, Pen’kova NA, Bezgina YeN. Compensatory changes of goldfish mauthner neurons induced by sensory stimulation and beta-amyloid application. Morfologiya. 2018;154(4):13-19. Russian.
Cochran JN, Hall AM, Roberson ED. The dendritic hypothesis for Alzheimer’s disease pathophysiology. Brain Res. Bull. 2014;103:18-28.
Kokanova NA, Mikhailova GZ, Shtanchayev RS, Tiras NR, Moshkov DA, Bezgina EN. Morphofunctional and ultrastructural consequences of application of beta-amyloid on goldfish mauthner neurons. Neurophysiology. 2014;46(1):33-42.
Moreno-Castilla P, Rodriguez-Duran LF, Guzman-Ramos K, Barcenas-Femat A, Escobar ML, Bermudez-Rattoni F. Dopaminergic neurotransmission dysfunction induced by amyloid-β transforms cortical long-term potentiation into long-term depression and produces memory impairment. Neurobiol. Aging. 2016;41:187-199.
Pedersen SF, Hoffmann EK, Mills JW. The cytoskeleton and cell volume regulation. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2001;130(3):385-399.
Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, von der Kammer H, Remy S. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer’s disease. Neuron. 2014;84(5):1023-1033.
Tiras NR, Mikhailova GZ, Moshkov DA. Effects induced by an actin-polymerizing peptide in goldfish mauthner neurons. Neurophysiology. 2006;38(5-6):327-337.
Tiras NR, Pen’kova NA, Besgina YN, Moshkov DA, Alilova GA. Changes in motor asymmetry of the goldfish related to adaptation to vestibular stimulation and applications of beta-amyloid on mauthner cells. Neurophysiology. 2015;47(2):115-127.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 2, pp. 230-234, February, 2020
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Tiras, N.R., Mikheeva, I.B., Mikhailova, G.Z. et al. Dopamine Improves Resistance of Dendrites of Mauthner Neurons to Destruction Induced by Sensory Stimulation and Application of Β-Amyloid. Bull Exp Biol Med 169, 266–269 (2020). https://doi.org/10.1007/s10517-020-04865-y
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DOI: https://doi.org/10.1007/s10517-020-04865-y