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Effect of Sulfated Polysaccharides from Marine Hydrobionts on Humoral Immune Response to Ovalbumin in Mice

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Adjuvant activity of fucoidans in experimental vaccine compositions with ovalbumin was studied on a mouse model. Compositions with sulfated polysaccharides from brown alga Fucus evanescens (native fucoidan in combination with polyphenols, and a product of fucoidan enzymatic hydrolysis) induced multiple productions of antigen-specific antibodies — total IgG, its isotypes IgG1 and, especially, IgG2a, in comparison with an individual ovalbumin. The adjuvant effect of native and structurally modified fucoidans is slightly inferior to that of the traditional licensed aluminum hydroxide adjuvant. The results indicate the prospects of using sulfated polysaccharides from F. evanescens as adjuvants in vaccines.

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Authors and Affiliations

  1. Laboratory of Immunology, G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia

    E. V. Persiyanova & T. A. Kuznetsova

  2. Laboratory of Enzyme Chemistry, G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia

    A. S. Silchenko

Authors
  1. E. V. Persiyanova
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  2. T. A. Kuznetsova
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  3. A. S. Silchenko
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Corresponding author

Correspondence to E. V. Persiyanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 2, pp. 207-210, February, 2020

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Persiyanova, E.V., Kuznetsova, T.A. & Silchenko, A.S. Effect of Sulfated Polysaccharides from Marine Hydrobionts on Humoral Immune Response to Ovalbumin in Mice. Bull Exp Biol Med 169, 246–248 (2020). https://doi.org/10.1007/s10517-020-04860-3

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  • DOI: https://doi.org/10.1007/s10517-020-04860-3

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