Skip to main content

Advertisement

SpringerLink
Log in

Correction of Alcohol-Induced Damage to Mitochondria in Cardiac and Cerebral Cells by Derivatives of Neuroactive Amino Acids

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied LPO intensity and respiration of mitochondria in brain and heart cells of rats receiving 5% ethanol for 20 weeks and treated with derivatives of neuroactive amino acids. Chronic semicompulsory alcohol intoxication increased the concentration of LPO products in cardiac and cerebral mitochondria by 46 and 45% (diene conjugates), by 97 and 8% (diketones), and by 28 and 81% (malondialdehyde), respectively, reduced activity of antioxidant enzymes in cardiac and cerebral mitochondria by 24 and 45% (glutathione peroxidase) and by 22 and 26% (superoxide dismutase), respectively, and uncoupled the process of respiration and ATP synthesis, which manifested in a decrease in respiratory control (V3/V4 ratio according to Chance). Glutamic acid derivative Neuroglutam (26 mg/kg) and GABA derivative succicard (44 mg/kg) administered intraperitoneally daily for 28 days after termination of alcoholization decreased the levels of primary and secondary LPO products, up-regulated activity of antioxidant enzymes in mitochondria of the heart and brain, and moderated the mitochondrial dysfunction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Boitsov SA, Samorodskaya IV, Semyonov VYu. Role of medical and non-medical factors in mortality rate: alcohol. Sots. Klin. Psikhiatriya. 2016;26(2):97-105. Russian.

    Google Scholar 

  2. Petrov VI, Tjurenkov IN, Bagmetova VV, Samotrueva MA, Berestovitskaja VM, Vasil’eva OS, Ostrogljadov ES. Patent RU No. 2429834. Antidepressant, anxiolytic, neuroprotective and immunostimulating agent. Bull. No. 27. Published September 27, 2011.

  3. Perfilova VN, Tyurenkov IN. Possible mechanisms of the antianginal action of GABA derivatives. Eksp. Klin. Farmakol. 2005;68(5):68-71. Russian.

    CAS  PubMed  Google Scholar 

  4. Perfilova VN, Tyurenkov IN, Berestovitskaya VM, Vasil’eva OS. Cardioprotective effect of GABA derivatives under acute alcohol intoxication conditions. Eksp. Klin. Farmakol. 2006;69(4):23-27. Russian.

    CAS  PubMed  Google Scholar 

  5. Perfilova VN, Tyurenkov IN, Popova TA, Mokrousov IS, Prokof’ev II, Mikhailova LI, Zhakupova GA, Miroshnikova AS. Effect of New GABA Derivative on the Development of Oxidative Stress in Rats under Conditions of Acute Myocardial Ischemia and Reperfusion. Eksp. Klin. Farmakol. 2015;78(9):8-12. Russian.

    CAS  PubMed  Google Scholar 

  6. Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem. J. 2011;435(2):297-312.

    Article  CAS  Google Scholar 

  7. Lanza IR, Nair KS. Functional assessment of isolated mitochondria in vitro. Methods Enzymol. 2009;475:349-372.

    Article  Google Scholar 

  8. Obad A, Peeran A, Little JI, Haddad GE, Tarzami ST. Alcohol-mediated organ damages: heart and brain. Front. Pharmacol. 2018;9:81. https://doi.org/10.3389/fphar.2018.00081

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Piano MR. Alcohol’s effects on the cardiovascular system. Alcohol Res. 2017;38(2):219-241.

    PubMed  PubMed Central  Google Scholar 

  10. Piano MR, Phillips SA. Alcoholic cardiomyopathy: pathophysiologic insights. Cardiovasc. Toxicol. 2014;14(4):291-308.

    Article  CAS  Google Scholar 

  11. Song BJ, Akbar M, Abdelmegeed MA, Byun K, Lee B, Yoon SK, Hardwick JP. Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications. Redox Biol. 2014;3:109-123.

    Article  CAS  Google Scholar 

  12. Tapia-Rojas C, Mira RG, Torres AK, Jara C, Pérez MJ, Vergara EH, Cerpa W, Quintanilla RA. Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication. Birth Defects Res. 2017;109(20):1623-1639.

    Article  CAS  Google Scholar 

  13. Yang F, Luo J. Endoplasmic reticulum stress and ethanol neurotoxicity. Biomolecules. 2015;5(4):2538-2553.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Theoretical Physics with Clinical Biochemistry Course, Volgograd, Russia

    T. A. Popova, G. Kh. Khusainova, G. P. Dudchenko & O. V. Ostrovskii

  2. Department of Pharmacology and Biopharmacia, Advanced Medical Studies Faculty, Volgograd, Russia

    V. N. Perfilova, I. N. Tyurenkov, I. V. Malyuzhenko & N. S. Ganzikova

  3. Department of Forensic Medicine, Volgograd, Russia

    I. I. Prokofiev

  4. Department of Innovative Drug Synthesis, Research Center for Innovative Drugs, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia

    V. V. Bagmetova

Authors
  1. T. A. Popova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Kh. Khusainova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. I. Prokofiev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. N. Perfilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. N. Tyurenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. V. Bagmetova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. V. Malyuzhenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. S. Ganzikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. G. P. Dudchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. O. V. Ostrovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. I. Prokofiev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 2, pp. 176-181, February, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Popova, T.A., Khusainova, G.K., Prokofiev, I.I. et al. Correction of Alcohol-Induced Damage to Mitochondria in Cardiac and Cerebral Cells by Derivatives of Neuroactive Amino Acids. Bull Exp Biol Med 169, 218–223 (2020). https://doi.org/10.1007/s10517-020-04854-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-04854-1

Key Words

Search

Navigation