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Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres

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Bulletin of Experimental Biology and Medicine Aims and scope

Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.

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Authors and Affiliations

  1. Department of Morphology and Pathology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    I. V. Milto, V. V. Ivanova, N. M. Shevtsova & I. V. Sukhodolo

  2. Department of Molecular and Cellular Radiobiology, Seversk Biophysical Research Center, Federal Medical-Biological Agency of Russia, Seversk, Russia

    I. V. Milto

Authors
  1. I. V. Milto
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  2. V. V. Ivanova
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  3. N. M. Shevtsova
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  4. I. V. Sukhodolo
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Correspondence to I. V. Milto.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 12, pp. 749-752, December, 2019

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Milto, I.V., Ivanova, V.V., Shevtsova, N.M. et al. Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres. Bull Exp Biol Med 168, 785–788 (2020). https://doi.org/10.1007/s10517-020-04802-z

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  • DOI: https://doi.org/10.1007/s10517-020-04802-z

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