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Peptide KE in Human Proteome

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Bulletin of Experimental Biology and Medicine Aims and scope

Peptide KE exhibits immunoprotective, geroprotective, and oncostatic activities and stimulates functional activity of fibroblasts. The KE motif is present in amino acid sequences of some cytokines and peptide hormones functionally similar to KE peptide. However, the relationship between the presence of KE motif and protein functions on the scale of known human proteome has not yet received sufficient attention. The incidence of bioregulatory peptide KE in proteins of various functional groups constituting human proteome is studied. The study is carried out with the use of the available data on the human proteome (UniProt portal) comprising 20,417 proteins. The levels of KE motifs were maximum in cytoplasmic and nuclear proteins, while the presence of KE in the membrane and all other proteins was the minimum. KE peptide molecules released from nuclear proteins during limited proteolysis can bind to DNA and regulate gene expression.

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Authors and Affiliations

  1. Department of Normal Physiology, Moscow, Russia

    A. Yu. Terekhov & A. T. Mar’yanovich

  2. Department of Geriatrics, Propedeutics, and Nursing Activity Management, I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia

    V. Kh. Khavinson

  3. Department of Biogerontology, St. Petersburg Research Center Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    D. Yu. Kormilets, N. S. Linkova & V. Kh. Khavinson

  4. Department of Therapy, Geriatrics, and Anti-Age Medicine, Academy for Continuous Education, Federal Research and Clinical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia

    N. S. Linkova

  5. Department of Normal Physiology, Chita State Medical Academy, the Ministry of Health of Russia, Chita, Russia

    B. I. Kuznik

Authors
  1. A. Yu. Terekhov
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  2. D. Yu. Kormilets
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  3. N. S. Linkova
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  4. B. I. Kuznik
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  5. A. T. Mar’yanovich
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  6. V. Kh. Khavinson
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Corresponding author

Correspondence to N. S. Linkova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 11, pp. 569-572, November, 2019

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Terekhov, A.Y., Kormilets, D.Y., Linkova, N.S. et al. Peptide KE in Human Proteome. Bull Exp Biol Med 168, 631–633 (2020). https://doi.org/10.1007/s10517-020-04767-z

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  • DOI: https://doi.org/10.1007/s10517-020-04767-z

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