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Plasma Cytokines Profile in Patients with Parkinson’s Disease Associated with Mutations in GBA Gene

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Plasma cytokine concentration in patients with Parkinson’s disease and mutation in GBA gene, in patients with sporadic Parkinson’s disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson’s disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and TNFα were revealed by ELISA in comparison with both controls and patients with sporadic form of Parkinson’s disease. Multiplex analysis revealed enhanced secretion of IL-1β, IL-2, IFNγ and reduced plasma levels of monocyte chemoattractant protein-1 (MCP-1) in patients with Parkinson’s disease and mutation in GBA gene (in comparison with other groups) and increased plasma levels of IL-13 (only in comparison with the healthy volunteers). Our results support the hypothesis that the concentrations of inflammatory mediators are increased in patients with Parkinson’s disease and mutation in GBA gene.

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Authors and Affiliations

  1. Institute of Experimental Medicine, St. Petersburg, Russia

    I. V. Miliukhina, K. A. Senkevich & S. N. Pchelina

  2. Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

    I. V. Miliukhina, T. S. Usenko, K. A. Senkevich, M. A. Nikolaev, A. A. Timofeeva, A. V. Semenov, A. A. Totolyan & S. N. Pchelina

  3. B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, Gatchina, Leningrad region, Russia

    I. V. Miliukhina, T. S. Usenko, K. A. Senkevich, M. A. Nikolaev, E. A. Agapova & S. N. Pchelina

  4. Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

    A. V. Semenov, N. E. Lubimova & A. A. Totolyan

Authors
  1. I. V. Miliukhina
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  2. T. S. Usenko
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  3. K. A. Senkevich
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  4. M. A. Nikolaev
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  5. A. A. Timofeeva
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  6. E. A. Agapova
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  7. A. V. Semenov
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  8. N. E. Lubimova
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  9. A. A. Totolyan
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  10. S. N. Pchelina
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Corresponding author

Correspondence to I. V. Miliukhina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 10, pp. 404-407, October, 2019

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Miliukhina, I.V., Usenko, T.S., Senkevich, K.A. et al. Plasma Cytokines Profile in Patients with Parkinson’s Disease Associated with Mutations in GBA Gene. Bull Exp Biol Med 168, 423–426 (2020). https://doi.org/10.1007/s10517-020-04723-x

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  • DOI: https://doi.org/10.1007/s10517-020-04723-x

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