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Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats

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We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH15-18PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced.

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Authors and Affiliations

  1. Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    T. A. Shubina, T. Yu. Obergan, L. A. Lyapina & M. E. Grigorieva

  2. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    N. F. Myasoedov & L. A. Andreeva

Authors
  1. T. A. Shubina
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  2. T. Yu. Obergan
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  3. L. A. Lyapina
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  4. M. E. Grigorieva
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  5. N. F. Myasoedov
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  6. L. A. Andreeva
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Corresponding author

Correspondence to T. A. Shubina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 8, pp. 205-208, August, 2019

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Shubina, T.A., Obergan, T.Y., Lyapina, L.A. et al. Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats. Bull Exp Biol Med 168, 250–253 (2019). https://doi.org/10.1007/s10517-019-04685-9

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  • DOI: https://doi.org/10.1007/s10517-019-04685-9

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