The effects of bariatric surgeries (sleeve gastrectomy and ileal transposition) on the dynamics of changes in ghrelin level were studied in rats with severe decompensated type 2 diabetes mellitus under conditions of glucose challenge as well as on the size of myocardial infarction in these animals. Diabetes was modelled by high fat diet and a single administration of streptozotocin (25 mg/kg, intraperitoneally). Both bariatric surgeries significantly decreased glucose-induced ghrelin level in the blood of rats with type 2 diabetes mellitus, which attested to an increase in the tissue sensitivity to ghrelin. Sleeve gastrectomy resulted in a decrease in the size of myocardial infarction in diabetic rats, which was calculated as the ratio of the necrosis zone to the zone of the risk of myocardial infarction. Ileal transposition had no effect on this parameter. Our data can be used as the basis for optimization of treatment approaches when using bariatric surgery in the treatment of patients with severe forms of type 2 diabetes mellitus with a high risk of cardiovascular diseases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Babenko AYu, Neymark AE, Anisimova KA, Grinyova EN. Effects of bariatric surgery on the level of hormones that regulate body weight. What is the basis of success? Ozhirenie Metabolizm. 2014;11(4):3-11. Russian.
Kornyushin OV, Toropova YaG, Neimark AE, Berko OM, Glistenkova DD, Carelli LG, Polozov AS, Galagudza MM. Surgical correction of metabolic syndromes in rats: methodological aspects. Byull. Sib. Med. 2018;17(1):59-74. Russian.
Korniushyn OV, Toropova JG, Semikova GV, Neimark AE, Dora SV, Davidova EE, Carelli L, Tkachuk OV, Markitantova AS. Pathophysiological aspects of pleiotropic effects of gastrointestinal hormones. Eksp. Klin. Gasrtoenterol. 2016;(10):4-14. Russian.
Tichonenko EV, Tsoi UA, Vasilieva EYu, Babenko AYu. Characteristics of eating behavior and the level of hormones regulating the appetite in patients with type 2 diabetes mellitus and body mass index more than 35 kg/m2. Ozhirenie Metabolizm. 2018;15(1):30-38. Russian.
Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724-1737.
Dedov I, Shestakova M, Benedetti MM, Simon D, Pakhomov I, Galstyan G. Prevalence of type 2 diabetes mellitus (T2DM) in the adult Russian population (NATION study). Diabetes Res. Clin. Pract. 2016;115:90-95.
Derkach KV, Bondareva VM, Chistyakova OV, Berstein LM, Shpakov AO. The Effect of long-term intranasal serotonin treatment on metabolic parameters and hormonal signaling in rats with high-fat diet/low-dose streptozotocin-induced type 2 diabetes. Int. J. Endocrinol. 2015;2015. ID 245459. doi: https://doi.org/10.1155/2015/245459
Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215-2222.
Frascarelli S, Ghelardoni S, Ronca-Testoni S, Zucchi R. Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Basic Res. Cardiol. 2003;98(6):401-405.
Kuhre RE, Gribble FM, Hartmann B, Reimann F, Windeløv JA, Rehfeld JF, Holst JJ. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. Am. J. Physiol. Gastrointest. Liver Physiol. 2014;306(7):G622-G630.
Mao Y, Tokudome T, Otani K, Kishimoto I, Nakanishi M, Hosoda H, Miyazato M, Kangawa K. Ghrelin prevents incidence of malignant arrhythmia after acute myocardial infarction through vagal afferent nerves. Endocrinology. 2012; 153:3426-3434.
Poher AL, Tschöp MH, Müller TD. Ghrelin regulation of glucose metabolism. Peptides. 2018;100:236-242.
Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J. Clin. Endocrinol. Metab. 2002;87(1):240-244.
St-Pierre DH, Karelis AD, Coderre L, Malita F, Fontaine J, Mignault D, Brochu M, Bastard JP, Cianflone K, Doucet E, Imbeault P, Rabasa-Lhoret R. Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women. J. Clin. Endocrinol. Metab. 2007;92:264-269.
Tong J, Davis HW, Gastaldelli A, D’Alessio D. Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1. J. Clin. Endocrinol. Metab. 2016;101:2405-2414.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 8, pp. 161-165, August, 2019
Rights and permissions
About this article
Cite this article
Kornyushin, O.V., Sonin, D.L., Toropova, Y.G. et al. Effects of Bariatric Surgeries on the Size of Myocardial Infarction and Ghrelin Level in Rats with Experimental Decompensated Type 2 Diabetes Mellitus. Bull Exp Biol Med 168, 210–213 (2019). https://doi.org/10.1007/s10517-019-04676-w
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04676-w