We studied the effect of hypokinesia combined with cold exposure on morphological parameters of the heart in Wistar-Kyoto rats and rats with spontaneous genetically determined hypertension (SHR). The pathological processes developing in the heart of white laboratory rats significantly affected cardiac function and manifested in the deterioration of the morphological structure of the heart: reduction of heart weight, thinning of the free wall of the left ventricle. These changes indicate transition to a lower energy level of functioning. At the same time, hypertrophy of the right free wall develops in both rat lines. Combined effect of hypokinesia and cold is probably a factor indirectly promoting the development of pulmonary heart.
Similar content being viewed by others
References
Zaripova RI, Andrianov VV, Yafarova GG, Gainutdinov KhL, Khabibrakhmanov II, Zefirov TL. Influence of hypokinesia of varying duration on the nitric oxide productions dynamics in rat’s heart, spinal cord and liver. Ross. Fiziol. Zh. 2014;100(8):926-935. Russian.
Kibler NA, Nuzhny VP, Shmakov DN. Isoprenaline Impairs Contractile Function of Ventricular Myocardium in Common Frog (Rana temporaria). Bull. Exp. Biol. Med. 2018; 165(5):606-609.
Kruchkova YaA. Adaptation of children with disabilities in the modern world. Molodoi Uchenyi. 2017;(24):334-337. Russian.
Kurochkina ON, Nuzhny VP. Vascular continuum in patients with terminal renal failure in the North. Izv. Komi Nauch. Tsentra Ural. Otdel. Ross. Akad. Nauk. 2012;(4):49-53. Russian.
Limankina IN. Takotsubo cardiomyopathy. Vestn. Aritmol. 2009;(56):48-58. Russian.
Maltseva NG, Kuznetsova TG. Hypokinesia influence on myocardium strukture. Probl. Zdorov’ya Ekologii. 2008;7(2):113-118. Russian.
Tkachenko A. V. Metabolic processes in the heart and liver of experimental rats under conditions of experimental hypokinesia and their correction with herbal syrup Paleocon. Vestn. Khar’kov. Nats. Univer. im. V. N. Karazina. Ser.: Biol. 2011. Issue 971(14):177-184. Russian.
Tkachenko ВI, Sidorov PI. Circumpolar medicine: strategy of development. Med. Akad. Zh. 2007;(4):1-17. Russian.
Folkow B. Mental Stress and Its Importance for Cardiovascular Disorders. Kardiologiya. 2007;47(10):4-11. Russian.
Koch NS, Gratsianova AD. Effects of hypokinesia combined with cold exposure on morphofunctional state of the thyroid gland. Vestn. Tomsk. Gos. Ped. Univer. 2000;(9):52-55. Russian.
Chernova IM, Luk’yanov MM, Serdyuk SE, Boitsov SA. Peculiarities of risk factors, mechanisms of development, clinical course, and damage to the target organs in young hypertensive patients. Sistem. Gipertenzii. 2012;9(3):60-65. Russian.
Banegas JR, Rodríguez-Artalejo F, de la Cruz Troca JJ, Guallar-Castillón P, del Rey Calero J. Blood pressure in Spain: distribution, awareness, control, and benefits of a reduction in average pressure. Hypertension. 1998;32(6):998-1002.
Björntorp P, Holm G, Rosmond R, Folkow B. Hypertension and the metabolic syndrome: closely related central origin? Blood Press. 2000;9(2-3):71-82.
Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Murray CJ, Naghavi M. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: the Global Burden of Disease 2010 study. Circulation. 2014;129(14):1483-1492.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 6, pp. 731-738, June, 2019
Rights and permissions
About this article
Cite this article
Shmakov, D.N., Nuzhny, V.P. & Kibler, N.A. Combined Effects of Hypokinesia and Ambient Temperature on Heart Remodeling in Normotensive and Hypertensive Rats. Bull Exp Biol Med 167, 720–722 (2019). https://doi.org/10.1007/s10517-019-04607-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04607-9