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Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

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The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    L. G. Kolik, A. V. Nadorova, T. A. Antipova, S. V. Kruglov, V. S. Kudrin & A. D. Durnev

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  1. L. G. Kolik
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  2. A. V. Nadorova
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  3. T. A. Antipova
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  4. S. V. Kruglov
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  5. V. S. Kudrin
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  6. A. D. Durnev
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Corresponding author

Correspondence to L. G. Kolik.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 5, pp. 581-585, May, 2019

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Kolik, L.G., Nadorova, A.V., Antipova, T.A. et al. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bull Exp Biol Med 167, 641–644 (2019). https://doi.org/10.1007/s10517-019-04588-9

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  • DOI: https://doi.org/10.1007/s10517-019-04588-9

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