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Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors

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Bulletin of Experimental Biology and Medicine Aims and scope

We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.

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References

  1. Vedunova MV, Korotchenko SA, Balashova AN, Isakova OA, Khaspekov LG, Kazantsev VB, Mukhina IV. Effect of short-term glucose deprivation on the functioning of neuronal network in primary hippocampal culture on a multielectrode matrix. Sovremen. Tekhnol. Med. 2011;(2):7-13. Russian.

  2. Gusev EI, Skvortsova VI. Cerebral Ischemia. Moscow, 2001. Russian.

  3. Zozulya YuA, Baraboi VA, Sutkovoi DA. Free-Radical Lipid Oxidation and Antioxidant Defense in Brain Pathology. Moscow, 2000. Russian.

  4. Luk’yanova LD, Kirova YuI, Sukoyan GV. Signal mechanisms of adaptation to hypoxia and their role in systemic regulation. Biol. Membrany. 2012;29(4):238-252. Russian.

  5. Markin SP. Modern approach to the diagnosis and treatment of chronic brain ischemia.. Russ. Med. Zh. 2010;18(8):445-450. Russian.

  6. Mishchenko TA, Mitroshina EV, Shishkina TV, Vedunova MB. Antioxidant Properties of Glial Cell-Derived Neurotrophic Factor (GDNF). Bull. Exp. Biol. Med. 2018;166(2):293-296.

    Article  CAS  Google Scholar 

  7. Skvortsova VI, Evzel’man MA. Ischemic Stroke. Orel, 2006.

  8. Shirokova OM, Frumkina LE, Vedunova MV, Mitroshina EV, Zakharov YuN, Khaspekov LG, Mukhina IV. Morphofunctional regularities of the development of neural networks in dissociated hippocampal cultures in vitro. Sovremen. Tekhnol. Med. 2013;5(2):6-13. Russian.

  9. Budni J, Bellettini-Santos T, Mina F, Garcez ML, Zugno AI. The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease. Aging Dis. 2015;6(5):331-341.

    Article  Google Scholar 

  10. Chiang PL, Chen HL, Lu CH, Chen YS, Chou KH, Hsu TW, Chen MH, Tsai NW, Li SH, Lin WC. Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment. J. Neuroinflammation. 2018;15(1). ID 281. doi: 10.1186/s12974-018-1317-z.

  11. Han D, Chen S, Fang S, Liu S, Jin M, Guo Z, Yuan Y, Wang Y, Liu C, Mei X. The neuroprotective effects of muscle-derived stem cells via Brain-Derived Neurotrophic Factor in spinal cord injury model. Biomed. Res. Int. 2017;2017. ID 1972608. doi: 10.1155/2017/1972608

  12. Hertz L. Bioenergetics of cerebral ischemia: a cellular perspective. Neuropharmacology. 2008;55(3):289-309.

    Article  CAS  Google Scholar 

  13. Hwang IC, Kim JY, Kim JH, Lee JE, Seo JY, Lee JW, Park J, Yang HM, Kim SH, Cho HJ, Kim HS. Therapeutic potential of a novel necrosis inhibitor, 7-amino-indole, in myocardial ischemia-reperfusion injury. Hypertension. 2018;71(6):1143-1155.

    Article  CAS  Google Scholar 

  14. Kirkman MA, Smith M. Brain oxygenation monitoring. Anesthesiol Clin. 2016;34(3):537-556.

    Article  Google Scholar 

  15. Konishi Y, Yang LB, He P, Lindholm K, Lu B, Li R, Shen Y. Deficiency of GDNF receptor GFRα1 in Alzheimer’s neurons results in neuronal death. J. Neurosci. 2014;34(39):13,127-13,138.

  16. Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J. BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity. Cell Mol. Neurobiol. 2018;38(3):579-593.

    Article  CAS  Google Scholar 

  17. Lorigados Pedre L, Gallardo JM, Morales Chacón LM, Vega García A, Flores-Mendoza M, Neri-Gómez T, Estupiñán Díaz B, Cruz-Xenes RM, Pavón Fuentes N, Orozco-Suárez S. Oxidative stress in patients with drug resistant partial complex seizure. Behav. Sci. (Basel). 2018;8(6). pii: E59. doi: 10.3390/bs8060059

  18. Mercado NM, Collier TJ, Sortwell CE, Steece-Collier K. BDNF in the aged brain: translational implications for Parkinson’s disease. Austin Neurol. Neurosci. 2017;2(2). pii: 1021.

  19. Olmez I, Ozyurt H. Reactive oxygen species and ischemic cerebrovascular disease. Neurochem. Int. 2012;60(2):208-212.

    Article  CAS  Google Scholar 

  20. Shen T, You Y, Joseph C, Mirzaei M, Klistorner A, Graham SL, Gupta V. BDNF polymorphism: a review of its diagnostic and clinical relevance in neurodegenerative disorders. Aging Dis. 2018;9(3):523-536.

    Article  Google Scholar 

  21. Tupurani MA, Padala C, Puranam K, Galimudi RK, Kupsal K, Shyamala N, Gantala S, Kummari R, Chinta SK, Hanumanth S.R. Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study. PeerJ. 2018;6. ID e5509. doi: 10.7717/peerj.5509.

  22. Vedunova MV, Mishchenko TA, Mitroshina EV, Mukhina IV. TrkB-mediated neuroprotective and antihypoxic properties of Brain-Derived Neurotrophic Factor. Oxid. Med. Cell. Longev. 2015;2015. ID 453901. doi: 10.1155/2015/453901

  23. Vedunova M, Sakharnova T, Mitroshina E, Perminova M, Pimashkin A, Zakharov Y, Dityatev A, Mukhina I. Seizurelike activity in hyaluronidase-treated dissociated hippocampal cultures. Front. Cell. Neurosci. 2013;7. ID 149. doi: 10.3389/fncel.2013.00149.

  24. Walker M, Xu XM. History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and its use for spinal cord injury repair. Brain Sci. 2018;8(6). pii: E109. doi: 10.3390/brainsci8060109

  25. Wurzelmann M, Romeika J, Sun D. Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury. Neural Regen. Res. 2017;12(1):7-12.

    Article  Google Scholar 

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Authors and Affiliations

  1. N. I. Lobachevsky Nizhny Novgorod National Research State University, Nizhny Novgorod, Russia

    E. V. Mitroshina, T. A Mishchenko, T. V. Shishkina & M. V. Vedunova

Authors
  1. E. V. Mitroshina
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  2. T. A Mishchenko
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  3. T. V. Shishkina
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  4. M. V. Vedunova
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Corresponding author

Correspondence to E. V. Mitroshina.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 121-127, June, 2019

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Mitroshina, E.V., Mishchenko, T.A., Shishkina, T.V. et al. Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors. Bull Exp Biol Med 167, 574–579 (2019). https://doi.org/10.1007/s10517-019-04574-1

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  • DOI: https://doi.org/10.1007/s10517-019-04574-1

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