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ARID1A, Prostaglandin E2, and Its Receptor as Possible Predictors of Malignant Transformation of the Endometrium in Endometriosis

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We studied the expression of ARID1A, prostaglandin E2 synthase, and prostaglandin E2 receptor in the endometrium and ovarian, peritoneal, and intestinal endometrioid heterotopies in women with endometriosis of young and middle reproductive age. ARID1A protein is a tumor suppressor, its expression reduced in different types of cancer. Prostaglandin E2 synthase and prostaglandin E2 receptor are involved in the signaling cascade of inflammatory reactions presumably underlying the development of endometriosis. In endometrioid heterotopies, expression of ARID1A was reduced in 1.2-4.0 times, the expression of prostaglandin E2 synthase and prostaglandin E2 receptor was reduced in 2.9-5.2 times These findings suggest that ARID1A, prostaglandin E2 synthase, and prostaglandin E2 receptor can be used as predictors of malignant transformation of endometrioid heterotopies in women with endometriosis.

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Authors and Affiliations

  1. Department of Biogerontology, Research Center St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    A. S. Dyatlova, N. S. Lin’kova, V. O. Polyakova & I. M. Kvetnoi

  2. Department of Therapy, Geriatrics, and Anti-Age Medicine, Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Medical-Biological Agency, Moscow, Russia

    N. S. Lin’kova

  3. D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine, St. Petersburg, Russia

    V. O. Polyakova, N. G. Samoshkin & I. M. Kvetnoi

Authors
  1. A. S. Dyatlova
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  2. N. S. Lin’kova
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  3. V. O. Polyakova
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  4. N. G. Samoshkin
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  5. I. M. Kvetnoi
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Correspondence to N. S. Lin’kova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 493-496, April, 2019

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Dyatlova, A.S., Lin’kova, N.S., Polyakova, V.O. et al. ARID1A, Prostaglandin E2, and Its Receptor as Possible Predictors of Malignant Transformation of the Endometrium in Endometriosis. Bull Exp Biol Med 167, 504–507 (2019). https://doi.org/10.1007/s10517-019-04560-7

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  • DOI: https://doi.org/10.1007/s10517-019-04560-7

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