We analyzed biocompatibility, elastic-strength properties, and biointegration potential of a new biomaterial made of xenopericardium for reconstructive cardiovascular surgery. The biomaterial manufactured by the proposed technology demonstrated high biocompatibility and biointegration potential and its elastic-strength properties 2-4-fold surpassed that of native pericardium. The obtained results attested to good prospects of using the proposed technology for preparing biomaterials for reconstructive cardiovascular surgery.
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Akatov VS, Muratov RM, Fadeeva IS, Sachkov AS, Britikov DV, Fesenko NI, Soloviev VV, Chekanov AV. The study of biocompatibility of heart value transplants devitalized by anticalcinosis treatment. Geny Kletki. 2010;5(2):36-41. Russian.
Akatov VS, Muratov RM, Ryndina NI, Solov’ev VV, Britikov DV. Patent RU No. 2291675. Method for treating cardiovascular surgical transplants. Bull. No. 2. Published January 20, 2007.
Fadeeva IS, Akatov VS, Muratov RM, Britikov DV, Sachkov AS. Patent RU No. 2499611. Method for improving biocompatibility of valve and vascular grafts.. Bull. No. 33. Published November 27, 2013.
Aguiari P, Fiorese M, Iop L, Gerosa G, Bagno A. Mechanical testing of pericardium for manufacturing prosthetic heart valves. Interact. Cardiovasc. Thorac. Surg. 2016;22(1):72-84.
Morticelli L, Thomas D, Roberts N, Ingham E, Korossis S. Investigation of the suitability of decellularized porcine pericardium in mitral valve reconstruction. J. Heart Valve Dis. 2013;22(3):340-353.
Muratov R, Britikov D, Sachkov A, Akatov V, Soloviev V, Fadeeva I, Bockeria L. New approach to reduce allograft tissue immunogenicity. Experimental data. Interact. Cardiovasc. Thorac. Surg. 2010;10(3):408-412.
Schoen FJ, Levy RJ. Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann. Thorac. Surg. 2005;79(3):1072-1080.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 483-487, April, 2019
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Fadeeva, I.S., Sorkomov, M.N., Zvyagina, A.I. et al. Study of Biointegration and Elastic-Strength Properties of a New Xenopericardium-Based Biomaterial for Reconstructive Cardiovascular Surgery. Bull Exp Biol Med 167, 496–499 (2019). https://doi.org/10.1007/s10517-019-04558-1
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DOI: https://doi.org/10.1007/s10517-019-04558-1