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Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss

A total of 100 women with early pregnancy loss were recruited and further classified into two subgroups: sporadic pregnancy loss and recurrent pregnancy loss; each subgroup consisted of 50 women. The control group included 56 women with normal pregnancies. Genotyping was performed by PCR with restriction fragment length polymorphism analysis. A statistically significant increase in the frequencies of TT genotype and T allele for DNMT3B rs2424913 polymorphism was found in the total patient group and in both patient subgroups in comparison with the control. Moreover, homozygous TT genotype was associated with increased risk of early pregnancy loss (both sporadic and recurrent). DNMT3B rs2424913 gene polymorphism in women can be used a marker of predisposition to early pregnancy loss and recurrent pregnancy loss.

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Correspondence to M. M. Azova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 459-462, April, 2019

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Azova, M.M., Ahmed, A.A., Ait Aissa, A. et al. Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss. Bull Exp Biol Med 167, 475–478 (2019). https://doi.org/10.1007/s10517-019-04553-6

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Key Words

  • DNA methyltransferases
  • early pregnancy loss
  • single nucleotide polymorphisms