Skip to main content

Advertisement

SpringerLink
Log in

Effects of Specific Inhibitor of Phosphodiesterase 7 at the Late Stage of Long-Term Potentiation in Murine Hippocampal Slices

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Second messengers cAMP and cGMP play an important role in synaptic plasticity and memory consolidation. The inhibitors of phosphodiesterases, enzymes hydrolyzing these cyclic nucleotides, are actively studied as potential drugs for the treatment of various cognitive disorders and depression. We studied the effects of a new inhibitor of phosphodiesterase 7 AGF2.20 on the formation of long-term potentiation in hippocampal slices. Administration of AGF2.20 (10 nM) in 90 min after weak tetanization prevented a decrease in the amplitude of excitatory post-synaptic potentials and stabilized long-term potentiation. These data attest to the involvement of phosphodiesterase 7 in the development of synaptic plasticity in the hippocampus. The inhibitor AGF2.20 is considered for the further analysis as a promising substance for the treatment of cognitive impairments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ahmad F, Murata T, Shimizu K, Degerman E, Maurice D, Manganiello V. Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets. Oral Dis. 2015;21(1):e25-e50.

    Article  CAS  Google Scholar 

  2. Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc. Natl Acad. Sci. USA. 1998;95(25):15 020-15 025.

    Article  CAS  Google Scholar 

  3. Bliss TV, Collingridge GL, Morris RG. Synaptic plasticity in health and disease: introduction and overview. Philos. Trans. R Soc. Lond. B Biol. Sci. 2014;369. ID 20130129. doi: https://doi.org/10.1098/rstb.2013.0129.

  4. Blokland A, Menniti FS, Prickaerts J. PDE Inhibition and cognition enhancement. Expert Opin. Ther. Pat. 2012;22(4):349-354.

    Article  CAS  Google Scholar 

  5. Bollen E, Akkerman S, Puzzo D, Gulisano W, Palmeri A, D’Hooge R, Balschun D, Steinbusch H. W, Blokland A, Prickaerts J. Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors. Neuropharmacology. 2015;95:361-366.

    Article  CAS  Google Scholar 

  6. Bollen E, Puzzo D, Rutten K, Privitera L, De Vry J, Vanmierlo T, Kenis G, Palmeri A, D’Hooge R, Balschun D, Steinbusch H. M, Blokland A, Prickaerts J. Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling. Neuropsychopharmacology. 2014;39(11):2497-2505.

    Article  CAS  Google Scholar 

  7. Francis SH, Blount MA, Corbin JD. Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. Physiol. Rev. 2011;91(2):651-690.

    Article  CAS  Google Scholar 

  8. García AM, Brea J, Morales-García JA, Perez DI, González A, Alonso-Gil S, Gracia-Rubio I, Ros-Simó C, Conde S, Cadavid MI, Loza MI, Perez-Castillo A, Valverde O, Martinez A, Gil C. Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. J. Med. Chem. 2014;57(20):8590-8607.

    Article  CAS  Google Scholar 

  9. Gewald R, Rueger C, Grunwald C, Egerland U, Hoefgen N. Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors. Bioorg. Med. Chem. Lett. 2011;21(22):6652-6656.

    Article  CAS  Google Scholar 

  10. Johansson EM, Reyes-Irisarri E, Mengod G. Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain. Neurosci. Lett. 2012;525(1):1-6.

    Article  CAS  Google Scholar 

  11. Lipina TV, Beregovoy NA, Tkachenko AA, Petrova ES, Starostina MV, Zhou Q, Li S. Uncoupling DISC1*D2R proteinprotein interactions facilitates latent inhibition in Disc1-L100P animal model of schizophrenia and enhances synaptic plasticity via D2 receptors. Front. Synaptic Neurosci. 2018;10. ID 31. doi: https://doi.org/10.3389/fnsyn.2018.00031.

  12. Lipina TV, Jekielek M, Beregovoy NA, Starostina MV, Palomo V, Perez DI, Martinez A, Roder JC. Inhibition of glycogen synthase kinase 3 prevents synaptic long-term depression and facilitates cognition in C57Bl/6J mice. Opera Medica et Physiologica. 2016;2(3):87-102. doi: https://doi.org/10.20388/OMP2016.002.0026.

    Article  Google Scholar 

  13. Nicoll RA. A Brief history of long-term potentiation. Neuron. 2017;93(2):281-290.

    Article  CAS  Google Scholar 

  14. Sanderson TM, Sher E. The role of phosphodiesterases in hippocampal synaptic plasticity. Neuropharmacology. 2013;74:86-95.

    Article  CAS  Google Scholar 

  15. Xu Y, Zhang HT, O’Donnell JM. Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders. Handb. Exp. Pharmacol. 2011;(204):447-485.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    N. A. Beregovoi & M. V. Starostina

  2. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia

    T. V. Lipina

Authors
  1. N. A. Beregovoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. V. Starostina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. V. Lipina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. A. Beregovoi.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 451-453, April, 2019

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Beregovoi, N.A., Starostina, M.V. & Lipina, T.V. Effects of Specific Inhibitor of Phosphodiesterase 7 at the Late Stage of Long-Term Potentiation in Murine Hippocampal Slices. Bull Exp Biol Med 167, 467–469 (2019). https://doi.org/10.1007/s10517-019-04551-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-019-04551-8

Key Words

Search

Navigation