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Effect of Electroconvulsive Therapy on Anxiety in Linear and Non-Linear Rats with Depressive-Like Disorders Induced by Ultrasound Stimulation

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Bulletin of Experimental Biology and Medicine Aims and scope

We performed a comparative study of the effect of electroconvulsive therapy on anxiety in outbred rats and Sprague-Dawley rats with depressive-like disorder induced by exposure to ultrasound of variable frequency (20-45 Hz). The anxiogenic effect of therapy was revealed in elevated plus maze and open-field tests in both linear and non-lineal rats, but was more pronounced in linear animals. Differences between outbred rats and Sprague-Dawley rats by the anxiety level were demonstrated. These results suggest that electroconvulsive therapy should be used with cautious in patients with depression and comorbid anxiety disorders. Pronounced behavioral differences between linear and non-linear rats should be considered when choosing optimal experimental object in this research field.

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Authors and Affiliations

  1. Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    V. М. Ushakova, Е. А. Zubkov, А. Yu. Morozova, Ya. А. Zorkina & V. P. Chekhonin

  2. Department of Higher Nervous Activity, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    V. М. Ushakova, А. V. Gorlova & А. N. Inozemtsev

  3. N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    V. P. Chekhonin

Authors
  1. V. М. Ushakova
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  2. А. V. Gorlova
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  3. Е. А. Zubkov
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  4. А. Yu. Morozova
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  5. Ya. А. Zorkina
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  6. А. N. Inozemtsev
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  7. V. P. Chekhonin
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Corresponding author

Correspondence to V. М. Ushakova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 424-427, April, 2019

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Ushakova, V.М., Gorlova, А.V., Zubkov, Е.А. et al. Effect of Electroconvulsive Therapy on Anxiety in Linear and Non-Linear Rats with Depressive-Like Disorders Induced by Ultrasound Stimulation. Bull Exp Biol Med 167, 443–445 (2019). https://doi.org/10.1007/s10517-019-04545-6

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  • DOI: https://doi.org/10.1007/s10517-019-04545-6

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