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The Structure of NO-Mediated Dilatation of Pulmonary Arteries Depends on NO Availability

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NO-mediated vasodilatation can be realized via two pathways: dependent and independent on soluble guanylate cyclase; the latter is implemented through NO interaction with ionic channels. We evaluated the contribution of these pathways into NO-induced relaxation of isolated pulmonary arteries in rats. In pulmonary arteries, in contrast to systemic vessels, soluble guanylate cyclase-independent mechanisms is more important, because it mediates relaxation in response to low concentrations of NO donor. The role of soluble guanylate cyclase-dependent mechanisms in the mechanisms of vasodilatation increases with increasing NO donor concentrations.

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Authors and Affiliations

  1. Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia

    M. P. Davydova

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  1. M. P. Davydova
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Correspondence to M. P. Davydova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 2, pp. 200-203, February, 2019

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Davydova, M.P. The Structure of NO-Mediated Dilatation of Pulmonary Arteries Depends on NO Availability. Bull Exp Biol Med 167, 247–249 (2019). https://doi.org/10.1007/s10517-019-04501-4

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  • DOI: https://doi.org/10.1007/s10517-019-04501-4

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