We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 2, pp. 175-178, February, 2019
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Mukhina, A.Y., Medvedeva, O.A., Svishcheva, M.V. et al. State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment. Bull Exp Biol Med 167, 226–228 (2019). https://doi.org/10.1007/s10517-019-04496-y
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DOI: https://doi.org/10.1007/s10517-019-04496-y