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Effect of Linagliptin on the Ratio of Apoptosis Regulators in the Model of Non-Alcoholic Fatty Liver Disease in db/db Mice

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We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin on the expression of apoptosis regulator proteins Bcl-2 and Bad in the liver of db/db mice with genetically determined obesity and type 2 diabetes mellitus. The mice received daily linagliptin or saline (placebo) by gavage from week 10 to week 18 of life. In the liver of non-treated mice, the area positively stained for Bad was greater than the area of Bcl-2 expression, which created the conditions for apoptosis activation in liver at this age. Administration of linagliptin decreased Bad stained area and increased Bcl-2 stained area in the liver cells. At the same time, Bad stained area remained larger in treated mice than the area of Bcl-2 expression area, which attested to partial normalization of pro- and antiapoptotic protein balance.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Novosibirsk, Russia

    S. V. Michurina, M. A. Cherepanova, I. Yu. Ishchenko, S. A. Arkhipov & V. V. Klimontov

  2. Federal Research Center Institute for Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    E. L. Zav’yalov

Authors
  1. S. V. Michurina
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  2. M. A. Cherepanova
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  3. I. Yu. Ishchenko
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  4. S. A. Arkhipov
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  5. V. V. Klimontov
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  6. E. L. Zav’yalov
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Corresponding author

Correspondence to S. V. Michurina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 2, pp. 157-162, February, 2019

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Michurina, S.V., Cherepanova, M.A., Ishchenko, I.Y. et al. Effect of Linagliptin on the Ratio of Apoptosis Regulators in the Model of Non-Alcoholic Fatty Liver Disease in db/db Mice. Bull Exp Biol Med 167, 210–214 (2019). https://doi.org/10.1007/s10517-019-04493-1

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  • DOI: https://doi.org/10.1007/s10517-019-04493-1

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